Cerebrovascular diseases (Basel, Switzerland) · 2026
Early-Life Factors and Risk of Brain Arteriovenous Malformations: A Prospective Cohort Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Zhisheng, Liu Junyu, Cao Fang, Wang Yuge, Wang Yaoyao, Zeng Hanyue, Zhou Mengna, Zhang Tiancheng, Li Yifeng, Jiang Weixi, Yan Junxia
Аннотация
INTRODUCTION: The pathophysiological basis of brain arteriovenous malformations (bAVMs) remains incompletely understood. Early-life factors are hypothesized to influence cerebrovascular development; however, their potential associations with bAVMs have not been systematically evaluated. This study aimed to investigate the associations between eight early-life factors and the risk of bAVMs.
METHODS: This prospective cohort study included 329,121 participants aged 40-69 years from the UK Biobank with complete covariate data at baseline. Multiple-adjusted logistic regression models were used to explore the associations between eight self-reported early-life factors (breastfed as a baby, part of a multiple birth, maternal smoking around birth, comparative body size at age 10, handedness, childhood sunburn occasions, number of older siblings, birth weight) and subsequent diagnosis of bAVMs.
RESULTS: A total of 141 patients were diagnosed with bAVMs. After multivariable adjustment, three early-life factors were associated with an increased risk of bAVMs: very low birth weight (<1.5 kg vs. 2.5-4.0 kg; odds ratio [OR], 3.27; 95% confidence interval [CI], 1.04-10.67), having one or more older siblings (≥1 person vs. none; OR, 1.83; 95% CI, 1.03-3.24), and frequent childhood sunburn (>10 episodes vs. none; OR, 2.83; 95% CI, 1.13-7.08). No statistically significant associations were observed in other early-life factors. Sensitivity analyses confirmed the robustness of these findings.
CONCLUSIONS: In this large prospective cohort, very low birth weight, the presence of older siblings, and repeated childhood sunburn were associated with a higher risk of bAVMs. These findings warrant validation and further investigation into the underlying biological mechanisms.
METHODS: This prospective cohort study included 329,121 participants aged 40-69 years from the UK Biobank with complete covariate data at baseline. Multiple-adjusted logistic regression models were used to explore the associations between eight self-reported early-life factors (breastfed as a baby, part of a multiple birth, maternal smoking around birth, comparative body size at age 10, handedness, childhood sunburn occasions, number of older siblings, birth weight) and subsequent diagnosis of bAVMs.
RESULTS: A total of 141 patients were diagnosed with bAVMs. After multivariable adjustment, three early-life factors were associated with an increased risk of bAVMs: very low birth weight (<1.5 kg vs. 2.5-4.0 kg; odds ratio [OR], 3.27; 95% confidence interval [CI], 1.04-10.67), having one or more older siblings (≥1 person vs. none; OR, 1.83; 95% CI, 1.03-3.24), and frequent childhood sunburn (>10 episodes vs. none; OR, 2.83; 95% CI, 1.13-7.08). No statistically significant associations were observed in other early-life factors. Sensitivity analyses confirmed the robustness of these findings.
CONCLUSIONS: In this large prospective cohort, very low birth weight, the presence of older siblings, and repeated childhood sunburn were associated with a higher risk of bAVMs. These findings warrant validation and further investigation into the underlying biological mechanisms.