Apremilast for refractory major recurrent aphthous stomatitis involving the posterior pharyngeal wall: a case report.

This case report describes a 37-year-old woman with refractory major recurrent aphthous stomatitis (RAS) who presented with a persistent 10-month posterior pharyngeal ulcer that was unresponsive to conventional treatments. Laboratory tests revealed elevated IL-6 and C-reactive protein. After excluding other related diseases, treatment with apremilast led to complete ulcer healing within 3 months, with normalization of IL-6 and no new ulcers during 8 months of follow-up. This case suggests the potential therapeutic benefits of apremilast in severe pharyngeal RAS refractory to conventional therapies.