Late-Onset Hypoparathyroidism-Induced Hypocalcemia in a Very Low Birth Weight Infant Caused by Undiagnosed Maternal Hyperparathyroidism.

OBJECTIVE

To describe a rare case of late-onset neonatal hypocalcemia in a very preterm infant caused by maternal adenoma-related hyperparathyroidism (HyperPT) and to discuss diagnostic and therapeutic implications.

STUDY

DESIGN

Case report of a preterm infant born at 29 weeks of gestation with very low birth weight. Clinical course, laboratory findings, maternal history, and management were reviewed to identify the etiology and guide treatment.

RESULTS

The infant developed transient, asymptomatic hypocalcemia during the neonatal period. Maternal evaluation revealed primary HyperPT due to a parathyroid adenoma as the underlying cause. The newborn responded to calcium supplementation and optimized vitamin D therapy.

CONCLUSION

Maternal HyperPT can cause delayed neonatal hypocalcemia even in preterm infants. Early recognition through coordinated maternal-neonatal evaluation is crucial. Optimal vitamin D administration and close interdisciplinary communication between obstetrics and neonatology are essential for prevention and management.