Severe disease exacerbation in a patient with neuromyelitis optica spectrum disorder during treatment with dimethyl fumarate.

BACKGROUND

Certain disease-modifying drugs for multiple sclerosis are known to be ineffective in treating neuromyelitis optica spectrum disorder (NMOSD), and can even induce subsequent relapses.

CASE PRESENTATION: Here, we report on a patient with NMOSD who was misdiagnosed with multiple sclerosis and experienced severe exacerbations 3 months following initiation of treatment with dimethyl fumarate. The patient developed severe relapse in the form of myelitis extending from the medulla down to the T1 vertebral level. Cord swelling seen as contrast enhancement on magnetic resonance imaging was observed. This swelling resulted in spastic hemiplegia with severe painful dysesthesia. After a diagnosis of NMOSD was confirmed, dimethyl fumarate was discontinued and treatment with azathioprine was initiated. Subsequently, although her neurological status stabilized, residual deficits persisted.

CONCLUSION

The case described here suggests that dimethyl fumarate is unsuitable for NMOSD treatment as it may cause disease exacerbations.