Salmonella Stanley ST29 carrying IncHI2/ST3-blaNDM-5 plasmid emerged in a 4-month-old infant with diarrhea.

Salmonella serovar Stanley ST29 is an emerging foodborne pathogen with community spread potential, while its carbapenem resistance remains uncommon. In a longitudinal pediatric case with diarrhea, two clonal ST29 isolates sampled 2 months apart revealed within-host evolutionary dynamics: Tn7051-mediated excision of blaNDM-5 from an IncHI2/ST3 plasmid. Moreover, phylogenomics connected the case isolate to strains from a healthy carrier and from food-chain-associated sources in the same region (17-18 SNPs), underscoring community dissemination and the need for One-Health surveillance.