International archives of allergy and immunology · 2026
The Effect of Comorbid Sjogren Syndrome Diagnosis on the Clinical Phenotype of Chronic Rhinosinusitis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Smith Aaron D, Lyons Catherine E, Borish Larry
Аннотация
INTRODUCTION: Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by exocrine gland dysfunction and a T1/T3-skewed inflammation. Chronic rhinosinusitis (CRS) is more prevalent in SS, most likely due to the specific cytokine milieu, and the loss of secretory glands and secretion-associated antimicrobials. However, the impact of SS on CRS immunopathology and symptomatology is unclear. This study evaluated whether CRS in SS patients exhibits a distinct clinical profile compared to CRS alone.
METHODS: In this retrospective study, 14 patients with comorbid SS and CRS were compared to 90 CRS patients without rheumatologic or other comorbid systemic disease. CRS severity was assessed using the Sino-Nasal Outcome Test (SNOT-22), Lund-Mackay Score (LMS), Lund-Kennedy Score (LKS), and T2 inflammatory markers (IgE, absolute eosinophil count, and nasal polyp presence).
RESULTS: Demographics were similar between groups. Objective disease burden was greatest in CRS with nasal polyps, with higher LMS (p < 0.001) and LKS (p < 0.001) than the other groups. Despite this, SS patients reported the highest SNOT-22 total scores (p = 0.027). SS showed significantly higher scores in several domains, including nasal obstruction (p < 0.001), ear fullness (p < 0.001), reduced concentration (p < 0.001), frustration or irritability (p = 0.022), and fatigue (p = 0.044), with trends for need to blow the nose (p = 0.051), thick nasal discharge (p = 0.073), facial pain or pressure (p = 0.063), waking up tired (p = 0.096), and reduced productivity (p = 0.052).
CONCLUSIONS: SS appears to confer a distinct CRS phenotype marked by heightened symptom burden not reflected by conventional disease metrics. This discrepancy may reflect neuroinflammatory amplification driven by SS's T1/T3 cytokine profile. These findings highlight the need for symptom-focused, multidisciplinary care in this population.
METHODS: In this retrospective study, 14 patients with comorbid SS and CRS were compared to 90 CRS patients without rheumatologic or other comorbid systemic disease. CRS severity was assessed using the Sino-Nasal Outcome Test (SNOT-22), Lund-Mackay Score (LMS), Lund-Kennedy Score (LKS), and T2 inflammatory markers (IgE, absolute eosinophil count, and nasal polyp presence).
RESULTS: Demographics were similar between groups. Objective disease burden was greatest in CRS with nasal polyps, with higher LMS (p < 0.001) and LKS (p < 0.001) than the other groups. Despite this, SS patients reported the highest SNOT-22 total scores (p = 0.027). SS showed significantly higher scores in several domains, including nasal obstruction (p < 0.001), ear fullness (p < 0.001), reduced concentration (p < 0.001), frustration or irritability (p = 0.022), and fatigue (p = 0.044), with trends for need to blow the nose (p = 0.051), thick nasal discharge (p = 0.073), facial pain or pressure (p = 0.063), waking up tired (p = 0.096), and reduced productivity (p = 0.052).
CONCLUSIONS: SS appears to confer a distinct CRS phenotype marked by heightened symptom burden not reflected by conventional disease metrics. This discrepancy may reflect neuroinflammatory amplification driven by SS's T1/T3 cytokine profile. These findings highlight the need for symptom-focused, multidisciplinary care in this population.