JAMA neurology · 2013
Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
Клинический случайСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Johnson David Y, Dunkelberger Diana L, Henry Maya, Haman Aissatou, Greicius Michael D, Wong Katherine, DeArmond Stephen J, Miller Bruce L, Gorno-Tempini Maria Luisa, Geschwind Michael D
Аннотация
OBJECTIVE: To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.
DESIGN: Case report.
SETTING: Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.
PATIENT: Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.
RESULTS: Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.
CONCLUSIONS: These findings expand the differential of primary progressive aphasia to include prion disease.
DESIGN: Case report.
SETTING: Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.
PATIENT: Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.
RESULTS: Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.
CONCLUSIONS: These findings expand the differential of primary progressive aphasia to include prion disease.