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DOI 10.1172/jci141374

Медицинская библиотека · The Journal of clinical investigation · 2020

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.

Skendros Panagiotis, Mitsios Alexandros, Chrysanthopoulou Akrivi, Mastellos Dimitrios C, Metallidis Simeon, Rafailidis Petros, Ntinopoulou Maria, Sertaridou Eleni, Tsironidou Victoria, Tsigalou Christina, Tektonidou Maria, Konstantinidis Theocharis, Papagoras Charalampos, Mitroulis Ioannis, Germanidis Georgios, Lambris John D, Ritis Konstantinos

Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

AIM: The study aimed to explore the association between duration of smartphone usage and tear film parameters in adolescents through a hospitalbased cross-sectional study.

MATERIAL AND

METHODS

A detailed history regarding smartphone usage was obtained, followed by tear film assessment for all the study participants. Tear meniscus height (TMH), Tear film break up time (TBUT), and Schirmer's I test were done for all participants. Then they were classified into four groups, based on daily smartphone usage: < 2 hours/day, 2-4 hours/day, 4-6 hours/day, and > 6 hours/day.

RESULTS

123 smartphone users of the adolescent age group aged 10-19 years (mean age: 16.6 ±2.8 years) were included. The mean values of tear film parameters were as follows: TMH was 0.25 ±0.1 mm, Schirmer's I was 17.7 ±9.2 mm, and TBUT was 10.5 ±5.7 seconds. Participants using smartphones for > 6 hours/day had a significantly higher prevalence of reduced TMH (< 0.25 mm) compared to those with lower usage durations (p < 0.0001). Similar trends were observed for Schirmer's I and TBUT values, indicating a statistically significant association between prolonged smartphone use and tear film dysfunction (p < 0.0001). Notably, 72.7% of eyes in the > 6 hours/day group exhibited tear film dysfunction, significantly higher than in other groups.

CONCLUSION

Prolonged smartphone use adversely affects tear film stability and ocular surface health in adolescents. Awareness and appropriate measures to limit excessive screen time are essential to prevent tear film dysfunction and associated ocular discomfort.

Для цитирования: Skendros Panagiotis, Mitsios Alexandros, Chrysanthopoulou Akrivi, Mastellos Dimitrios C, Metallidis Simeon, Rafailidis Petros, Ntinopoulou Maria, Sertaridou Eleni, Tsironidou Victoria, Tsigalou Christina, Tektonidou Maria, Konstantinidis Theocharis, Papagoras Charalampos, Mitroulis Ioannis, Germanidis Georgios, Lambris John D, Ritis Konstantinos. Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.. The Journal of clinical investigation. 2020. DOI: 10.1172/jci141374.

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