MedElevator
Войти в исследования Transplantation proceedings · 2026
Sequential or Simultaneous Portal-Arterial Reperfusion During Liver Transplantation: A Retrospective Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
da Silva Wilson Júnior Pereira, Terra Elizandra Letícia Vieira, Rodrigues Fernanda De Sousa, Feijó Mateus Silva, de Oliveira Alexandre Corrente, Moldão Catarina Marcos, Costa João Pedro Soares, Figueira Ana Virginia, Morato Tiago, Romeres Silas Gustavo Barboza, Bitencourt Danielle Sacchi, Rocha Henrique, Trevizoli Natália de Carvalho, Diaz Luiz Gustavo, de Campos Priscila Brizolla, Cajá Gabriel, Ullmann Raquel Francine Bundchen, Jorge Fernando, Watanabe André Luís Conde
Аннотация
BACKGROUND: Ischemia-reperfusion injury is a relevant complication in liver transplantation. Sequential (SeqR) and simultaneous reperfusion (SimR) techniques are the most commonly used strategies to reduce this injury; however, there is still no consensus regarding which technique provides better outcomes. This study compares these techniques in terms of graft recovery, complications, and patient survival.
MATERIALS AND METHODS: This retrospective study included 872 patients who underwent liver transplantation, divided into 2 groups according to the reperfusion technique used. Patient characteristics, intraoperative and postoperative outcomes, as well as recipient and graft mortality and survival, were analyzed. Continuous variables were analyzed using Student's t-test, and categorical variables using Pearson's chi-square test, with a significance level of 5%.
RESULTS: A total of 520 transplants were performed using SimR and 352 using SeqR. SimR was associated with shorter operative time (P < .001) and longer total ischemia time (P < .001). It was also associated with a higher incidence of biliary stricture (P = .032) and a lower rate of graft rejection (95% CI: 0.342-0.754; OR: 0.508; P < .001). Overall recipient survival was significantly higher in the SimR group (P = .002).
DISCUSSION AND CONCLUSIONS: In this study, the SimR technique was significantly associated with improved overall recipient survival, despite being associated with longer total ischemia time. SimR was also correlated with a higher incidence of biliary strictures but demonstrated a protective effect against graft rejection. These findings should be confirmed in prospective, randomized studies.
MATERIALS AND METHODS: This retrospective study included 872 patients who underwent liver transplantation, divided into 2 groups according to the reperfusion technique used. Patient characteristics, intraoperative and postoperative outcomes, as well as recipient and graft mortality and survival, were analyzed. Continuous variables were analyzed using Student's t-test, and categorical variables using Pearson's chi-square test, with a significance level of 5%.
RESULTS: A total of 520 transplants were performed using SimR and 352 using SeqR. SimR was associated with shorter operative time (P < .001) and longer total ischemia time (P < .001). It was also associated with a higher incidence of biliary stricture (P = .032) and a lower rate of graft rejection (95% CI: 0.342-0.754; OR: 0.508; P < .001). Overall recipient survival was significantly higher in the SimR group (P = .002).
DISCUSSION AND CONCLUSIONS: In this study, the SimR technique was significantly associated with improved overall recipient survival, despite being associated with longer total ischemia time. SimR was also correlated with a higher incidence of biliary strictures but demonstrated a protective effect against graft rejection. These findings should be confirmed in prospective, randomized studies.