FROM INFUSION REACTION TO IMMUNE CASCADE: A CASE OF SEQUENTIAL TAXANE AND CAPECITABINE TOXICITIES IN TRIPLE-NEGATIVE BREAST CANCER.

This case report describes a 61-year-old female with stage IIIc triple-negative breast cancer (TNBC) who experienced a sequence of distinct treatment-related toxicities: a hypersensitivity reaction to paclitaxel, taxane-induced pneumonitis during subsequent docetaxel therapy, and radiation recall dermatitis (RRD) triggered by capecitabine administered after the completion of radiotherapy. The pneumonitis was successfully managed with corticosteroids, and the RRD resolved with topical therapy and dose modification. This case highlights the complex interplay of immune-mediated toxicities and underscores the importance of vigilant monitoring, individualized treatment adjustments, and multidisciplinary care in patients receiving sequential taxane-based chemotherapy, radiotherapy, and fluoropyrimidines.