Journal of the Endocrine Society · 2026
The effect of GIP and GLP-2 on bone turnover in children with cerebral palsy or spinal muscular atrophy.
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Christiansen Charlotte B, Skov-Jeppesen Kirsa, Naume Marie M, Myrup Sille, Høj Astrid, Gasbjerg Lærke S, Holst Jens J, Hoei-Hansen Christina E, Ørngreen Mette C, Rosenkilde Mette M, Hartmann Bolette
Аннотация
BACKGROUND: Children with cerebral palsy (CP) and spinal muscular atrophy (SMA) are at high risk of low bone mineral density, fractures, and low muscle mass. The gut-derived hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) reduce bone resorption in adults, but their effects in pediatric populations with CP and SMA are unknown.
METHODS: In this preliminary study, 3 children (1 CP and 2 SMA) underwent 3 interventions: (1) oral liquid mixed-meal ingestion, (2) subcutaneous GIP+GLP-2 administration, and (3) placebo. Plasma levels of GIP, GLP-2, CTX (bone resorption), P1NP (bone formation), and parathyroid hormone (PTH) were measured over 240 minutes.
RESULTS: The liquid mixed-meal significantly reduced CTX levels, indicating suppressed bone resorption, while exogenous GIP+GLP-2 administration had no significant effect on CTX or P1NP. PTH levels decreased after GIP+GLP-2 administration but were unaffected by the liquid mixed-meal.
CONCLUSION: In these studies, exogenous GIP and GLP-2 unexpectedly did not modulate bone turnover in our children with CP or SMA. The study highlights the need for age- and disease-specific investigations into the gut-bone axis in pediatric populations.
METHODS: In this preliminary study, 3 children (1 CP and 2 SMA) underwent 3 interventions: (1) oral liquid mixed-meal ingestion, (2) subcutaneous GIP+GLP-2 administration, and (3) placebo. Plasma levels of GIP, GLP-2, CTX (bone resorption), P1NP (bone formation), and parathyroid hormone (PTH) were measured over 240 minutes.
RESULTS: The liquid mixed-meal significantly reduced CTX levels, indicating suppressed bone resorption, while exogenous GIP+GLP-2 administration had no significant effect on CTX or P1NP. PTH levels decreased after GIP+GLP-2 administration but were unaffected by the liquid mixed-meal.
CONCLUSION: In these studies, exogenous GIP and GLP-2 unexpectedly did not modulate bone turnover in our children with CP or SMA. The study highlights the need for age- and disease-specific investigations into the gut-bone axis in pediatric populations.