Clinical laboratory · 2026
Alpha Thalassemia-Related Diabetic Nephropathy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Wu Fan, Liu Bingqing, Wang Zhengjie
Аннотация
BACKGROUND: Thalassemia, an autosomal recessive hematologic disorder, causes renal dysfunction via chronic hypoxia, anemia, iron overload, and iron chelating agents. This case showed severe tubulointerstitial lesions with diabetic nephropathy.
METHODS: Comprehensive diagnostic evaluation included targeted laboratory investigations, renal imaging studies, percutaneous renal biopsy, and thalassemia genetic testing to elucidate etiological mechanisms.
RESULTS: Laboratory findings confirmed microcytic hypochromic anemia with renal impairment. Imaging studies revealed pulmonary embolism, splenomegaly, and lower extremity deep vein thrombosis. Genetic analysis identified α-thalassemia. Renal histopathology demonstrated stage III diabetic nephropathy with severe tubulointerstitial fibrosis and tubular atrophy.
CONCLUSIONS: Refractory anemia with renal dysfunction requires thalassemia exclusion. The cause of renal injury in thalassemia needs to be confirmed by renal biopsy.
METHODS: Comprehensive diagnostic evaluation included targeted laboratory investigations, renal imaging studies, percutaneous renal biopsy, and thalassemia genetic testing to elucidate etiological mechanisms.
RESULTS: Laboratory findings confirmed microcytic hypochromic anemia with renal impairment. Imaging studies revealed pulmonary embolism, splenomegaly, and lower extremity deep vein thrombosis. Genetic analysis identified α-thalassemia. Renal histopathology demonstrated stage III diabetic nephropathy with severe tubulointerstitial fibrosis and tubular atrophy.
CONCLUSIONS: Refractory anemia with renal dysfunction requires thalassemia exclusion. The cause of renal injury in thalassemia needs to be confirmed by renal biopsy.