Crypto-periodicity in Mansonella ozzardi.

Studying nycthemeral microfilarial density in eight carriers of Mansonella ozzardi, Nathan et al. concluded that there is an absence of periodicity in M. ozzardi in Trinidad. Re-examination of the results obtained shows evidence of crypto-periodicity. Two of the eight patients showed highly significant periodicity but the biorhythms appear to be almost out of phase, the respective peaks being at 18.00 hours and 02.00 hours. The six other patients showed no obvious periodicity; the calculated acrophases (peak hours), instead of being randomly spaced, regrouped with the preceding ones: late afternoon in two subjects and in the second half of the night for the other four. It is concluded that the apparent non-periodicity is due to the co-existence of two periodic forms, but these are markedly out of phase.