Brain sciences · 2026
Exercise Modulates Working Memory-Related Brain Activation Through Bidirectional Neural Mechanisms: An ALE Meta-Analysis of Longitudinal and Cross-Sectional fMRI Studies.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Jiayu, Wang Jun, Tang Wenshuang
Аннотация
BACKGROUND: Physical exercise improves working memory (WM) across the lifespan, yet the neural mechanisms underlying this benefit remain incompletely understood, and it is unclear whether intervention-induced neuroplastic changes and long-term exercise-related differences converge on common neural circuits.
METHODS: We systematically searched PubMed, Web of Science, PsycINFO, and CNKI through June 2026 and included 11 task-based fMRI studies (6 longitudinal interventions and 5 cross-sectional comparisons; 403 participants) reporting whole-brain activation coordinates. Activation likelihood estimation (ALE) meta-analyses were performed separately for activation increases and decreases within each design.
RESULTS: Longitudinal studies revealed exercise-induced activation increases in the bilateral cerebellum (posterior lobe, cerebellar tonsil) and decreases in the right thalamus. Cross-sectional studies revealed greater activation in the left middle temporal gyrus (BA 21) and reduced activation in the right cingulate gyrus (BA 24) and left caudate body among long-term exercisers relative to controls. Critically, the two designs yielded spatially non-overlapping patterns.
CONCLUSIONS: These findings support a dual-mechanism model in which exercise strengthens task-positive network engagement while optimizing the suppression of task-irrelevant processing. They further suggest that exercise shapes working memory circuitry across distinct, timescale-dependent neural circuits.
METHODS: We systematically searched PubMed, Web of Science, PsycINFO, and CNKI through June 2026 and included 11 task-based fMRI studies (6 longitudinal interventions and 5 cross-sectional comparisons; 403 participants) reporting whole-brain activation coordinates. Activation likelihood estimation (ALE) meta-analyses were performed separately for activation increases and decreases within each design.
RESULTS: Longitudinal studies revealed exercise-induced activation increases in the bilateral cerebellum (posterior lobe, cerebellar tonsil) and decreases in the right thalamus. Cross-sectional studies revealed greater activation in the left middle temporal gyrus (BA 21) and reduced activation in the right cingulate gyrus (BA 24) and left caudate body among long-term exercisers relative to controls. Critically, the two designs yielded spatially non-overlapping patterns.
CONCLUSIONS: These findings support a dual-mechanism model in which exercise strengthens task-positive network engagement while optimizing the suppression of task-irrelevant processing. They further suggest that exercise shapes working memory circuitry across distinct, timescale-dependent neural circuits.