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Войти в исследования Overall and Sex-Specific Predictors of Secukinumab Effectiveness in European Patients With Psoriatic Arthritis: Results From the EuroSpA Collaboration.
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Heberg Jette, Georgiadis Stylianos, Ahmadzay Zohra Faizy, Glintborg Bente, Castrejón Isabel, Kazemi Mehrdad Shoae, Loft Anne Gitte, Michelsen Brigitte, Rasmussen Simon Horskjær, Laas Karin, Vorobjov Sigrid, Sánchez-Alonso Fernando, Rotar Ziga, Pirkmajer Katja Perdan, Šenolt Ladislav, Gudbjornsson Bjorn, Gröndal Gerdur, Codreanu Catalin, Iannone Florenzo, Atzeni Fabiola, Mann Heřman, Nordström Dan, Hokkanen Anna-Mari, Garcia Jorge, Barcelos Filipe, Mielnik Pawel, Kvien Tore K, Kenar-Artin Gokce, van de Sande Marleen, Nissen Michael J, Möller Burkhard, Olofsson Tor, Wallman Johan K, Hetland Merete Lund, Østergaard Mikkel, Ørnbjerg Lykke Midtbøll
Аннотация
METHODS: We analyzed data from 14 registries in the European Spondyloarthritis (EuroSpA) Research Collaboration. Patients aged ≥ 18 years at diagnosis, initiating SEC treatment from January 2015 to January 2021, were included. Multiple imputation was used for missing covariates at treatment start (baseline) and Disease Activity Index for Psoriatic Arthritis based on 28 joints (DAPSA28) at 6 months. Overall and sex-stratified analyses were performed by logistic and Cox regressions to identify baseline predictors of the following treatment outcomes: (1) DAPSA28 low disease activity (LDA; DAPSA28 ≤ 14) at 6 months, (2) DAPSA28 moderate response at 6 months, and (3) SEC discontinuation within 12 months.
RESULTS: In total, 2790 patients (43% male) were included. Median age was 43 years (IQR 34-52), and SEC was the first-line biologic/targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD) in 665 patients (24%). Positive predictors for both DAPSA28 LDA and DAPSA28 moderate response were male sex, fewer previous b/tsDMARDs, C-reactive protein (CRP) > 10 mg/L, and lower Health Assessment Questionnaire (HAQ) score. Absence of psoriasis, higher patient fatigue, and tender joint counts predicted SEC discontinuation within 12 months. For some outcomes, sex-specific predictors were fewer previous b/tsDMARDs and CRP > 10 mg/L among male patients and lower patient fatigue score among female patients.
CONCLUSION: We identified overall and sex-specific predictors of SEC effectiveness in European patients with PsA. Our findings may support personalized treatment decisions.