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Войти в исследования Head & neck · 2025
Greater Attention to Gingival Cancer and Floor of Mouth Cancer: Based on a Retrospective Analysis of Oral Cancer Across Different Subsites.
СтатьяНазвание и аннотация: Перевод в очереди
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Li Hao, Ding Yi, Wu Yansheng, Fang Yan, Li Xinhua, Shi Weifeng, Chen Shaoshi, Yang Ailin, Zhang Jin, Shi Ruoyu, Jing Chao, Wang Xudong, Duan Yuansheng
Аннотация
BACKGROUND: The gingiva and floor of the mouth are distinct subsites, and oral squamous cell carcinoma (OSCC) originating in these locations warrants further indepth understanding.
METHODS: This study enrolled patients with OSCC from 2000 to 2020, and analyzed the clinicopathological characteristics. Kaplan-Meier analysis compared overall survival (OS) and recurrence-free survival (RFS). Univariate analysis and multivariate Cox proportional hazards model examined the risk factors on survival outcomes.
RESULTS: A total of 885 OSCC patients were included, with the most common tumor subsites: oral tongue (41.9%), gingiva (31.8%), and floor of mouth (16.0%). Gingival and floor of mouth showed a higher proportion of advanced stage (65.8%, 66.9%) and significantly poorer OS (3-year: 63.0%, 57.0%; 5-year: 49.8%, 37.3%) and RFS (3-year: 59.1%, 61.3%; 5-year: 55.5%, 57.0%). Neoadjuvant chemotherapy was associated with significantly reduced mortality in gingival cancer (HR = 0.598), while tobacco exposure (HR = 1.952) was associated with a significant increase in mortality in floor of mouth cancer.
CONCLUSION: Gingival cancer and floor of mouth cancer have a worse prognosis, and thus require greater attention throughout the entire management process.
METHODS: This study enrolled patients with OSCC from 2000 to 2020, and analyzed the clinicopathological characteristics. Kaplan-Meier analysis compared overall survival (OS) and recurrence-free survival (RFS). Univariate analysis and multivariate Cox proportional hazards model examined the risk factors on survival outcomes.
RESULTS: A total of 885 OSCC patients were included, with the most common tumor subsites: oral tongue (41.9%), gingiva (31.8%), and floor of mouth (16.0%). Gingival and floor of mouth showed a higher proportion of advanced stage (65.8%, 66.9%) and significantly poorer OS (3-year: 63.0%, 57.0%; 5-year: 49.8%, 37.3%) and RFS (3-year: 59.1%, 61.3%; 5-year: 55.5%, 57.0%). Neoadjuvant chemotherapy was associated with significantly reduced mortality in gingival cancer (HR = 0.598), while tobacco exposure (HR = 1.952) was associated with a significant increase in mortality in floor of mouth cancer.
CONCLUSION: Gingival cancer and floor of mouth cancer have a worse prognosis, and thus require greater attention throughout the entire management process.