Is IFN-γ good or bad for the host during helminth infections?

IFN-γ function during a type-2 helminth infection remains enigmatic. Westfall et al. found an unexpected role for IFN-γ in limiting tissue damage during intestinal infection by Heligmosomoides polygyrus bakeri (Hpb). IFN-γ produced by CD8+ T cells stimulates stromal cells directly to recruit neutrophils, where they prevent tissue damage caused by the worms.