Journal of health, population, and nutrition · 2025
Association between weight-adjusted-waist index and the prevalence of gallstone disease in Minhang District, Shanghai: a cross-sectional study.
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Wang Jian, Zheng Zixuan, Tan Hongyu, Wei Shan, Gu Yufeng, Cheng Yingsheng, Xu Chengyan, Wang Wei
Аннотация
BACKGROUND: Gallstone disease (GSD) is a common and costly health issue with a multifactorial etiology linked to obesity. The Weight-Adjusted-Waist Index (WWI) is a novel anthropometric measure that incorporates both weight and waist circumference, potentially offering a better assessment of GSD risk associated with adiposity. This study aims to evaluate the association between WWI and the prevalence of GSD.
METHODS: We conducted a cross-sectional study involving 19,426 participants divided into stone (n = 4,398) and non-stone (n = 15,028) groups based on ultrasound-confirmed GSD. WWI was calculated, and its association with GSD was analyzed using logistic regression models, adjusting for confounders such as age, gender, and comorbid conditions.
RESULTS: The prevalence of GSD was 22.6%. Participants with GSD had a higher mean age, a greater proportion of females, and higher Body Mass Index (BMI) compared to those without GSD. WWI was significantly higher in the stone group (p < 0.001). The prevalence of fatty liver was also higher in the stone group (p < 0.001). Laboratory findings indicated a subclinical inflammatory state in participants with GSD. The highest tertile of WWI was associated with an increased odds ratio for GSD (OR = 1.23, 95% CI: 1.13-1.35 in the fully adjusted model). WWI demonstrates superior predictive ability for gallstones compared to other obesity markers in obese populations.
CONCLUSIONS: WWI is positively associated with the prevalence of GSD, independent of traditional risk factors. These findings suggest that WWI could serve as a practical screening tool to identify individuals at higher risk for GSD, emphasizing the need for targeted interventions to address central obesity.
METHODS: We conducted a cross-sectional study involving 19,426 participants divided into stone (n = 4,398) and non-stone (n = 15,028) groups based on ultrasound-confirmed GSD. WWI was calculated, and its association with GSD was analyzed using logistic regression models, adjusting for confounders such as age, gender, and comorbid conditions.
RESULTS: The prevalence of GSD was 22.6%. Participants with GSD had a higher mean age, a greater proportion of females, and higher Body Mass Index (BMI) compared to those without GSD. WWI was significantly higher in the stone group (p < 0.001). The prevalence of fatty liver was also higher in the stone group (p < 0.001). Laboratory findings indicated a subclinical inflammatory state in participants with GSD. The highest tertile of WWI was associated with an increased odds ratio for GSD (OR = 1.23, 95% CI: 1.13-1.35 in the fully adjusted model). WWI demonstrates superior predictive ability for gallstones compared to other obesity markers in obese populations.
CONCLUSIONS: WWI is positively associated with the prevalence of GSD, independent of traditional risk factors. These findings suggest that WWI could serve as a practical screening tool to identify individuals at higher risk for GSD, emphasizing the need for targeted interventions to address central obesity.