Syndrome of inappropriate secretion of antidiuretic hormone due to desvenlafaxine.

OBJECTIVE

Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is not uncommon in patients receiving treatment of selective serotonin reuptake inhibitors or venlafaxine.

METHOD: This is a case report of a 47-year-old man with depression, who developed hyponatremia after commencing treatment with desvenlafaxine.

RESULTS

To our knowledge, this is the first case in which desvenlafaxine-associated SIADH was reported since the introduction of the drug.

CONCLUSION

Physicians should be aware of the possibility of desvenlafaxine-associated hyponatremia in patients under age of 65.