Targeting cutaneous inflammation: A review on advanced topical delivery systems and precision medicine in psoriasis.

Psoriasis is a chronic autoimmune-mediated inflammatory skin disorder that is characterized by increased keratinocyte proliferation, abnormalities in the immune system, and abnormalities in the epidermal barrier. The conventional topical treatments for the management of psoriasis include corticosteroids, vitamin D analogues, and keratolytic. The long-term efficacy of these topical treatments for the management of psoriasis is marred by issues such as skin penetration difficulties, side effects, tachyphylaxis, and poor patient compliance. In recent times, nanotechnology-based drug delivery systems such as liposomes, transferosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid particles, and nano emulsions have been identified as potential therapeutic tools for the management of psoriasis. The nanotechnology-based drug delivery system has the potential to improve the solubility of the drug, permeability of the drug through the stratum corneum layer of the skin, and release and retention of the drug in the skin layer. In addition, the recent trends in the management of psoriasis have opened new avenues for the management of this condition. The review article discusses the pathology of psoriasis, the current treatment options for the management of psoriasis, and the recent advances in nanotechnology-based topical drug delivery for the management of psoriasis.