Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
Clinical Features and Management Outcomes of Temporal Bone Giant Cell Tumors: A Multi-case Analysis.
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Xue Songbo, Sun Huiying, Tian Xu, Zhao Yang, Gao Zhiqiang, Feng Guodong
Аннотация
OBJECTIVE: To study the clinical presentation, surgical strategies, and outcomes in patients diagnosed with temporal bone giant cell tumors based on long-term follow-up.
STUDY DESIGN: Retrospective cohort study.
SETTING: Single-institutional.
PATIENTS: This retrospective cohort study analyzed 7 patients with TB-GCTs treated from 2014 to 2024, evaluating clinical characteristics, surgical approaches, and outcomes.
INTERVENTIONS: Treatment by surgery.
MAIN OUTCOME MEASURES: The recurrence-free survival serves as the most essential criterion, aligning with the study's emphasis on surgical success and long-term prognosis.
RESULTS: Seven patients (4 males and 3 females) aged 25 to 63 years (median age: 45.9 y) presented with temporal bone giant cell tumors. The most common symptoms were hearing loss (100%), ear pain (85.7%), facial paralysis (42.8%), and tinnitus (42.8%). Imaging revealed tumor extension primarily to the temporal bone squamous part. Surgical strategies, including the single infratemporal fossa approach or combined infratemporal fossa approaches, achieved complete resection in all cases, with no recurrences during a median follow-up of 51 months.
CONCLUSIONS: Complete surgical resection with careful exposure is critical for minimizing recurrence. Our study highlights the efficacy of the single infratemporal fossa approach or combined infratemporal fossa approaches and emphasizes the need for further research into standardized staging and adjuvant therapies.
STUDY DESIGN: Retrospective cohort study.
SETTING: Single-institutional.
PATIENTS: This retrospective cohort study analyzed 7 patients with TB-GCTs treated from 2014 to 2024, evaluating clinical characteristics, surgical approaches, and outcomes.
INTERVENTIONS: Treatment by surgery.
MAIN OUTCOME MEASURES: The recurrence-free survival serves as the most essential criterion, aligning with the study's emphasis on surgical success and long-term prognosis.
RESULTS: Seven patients (4 males and 3 females) aged 25 to 63 years (median age: 45.9 y) presented with temporal bone giant cell tumors. The most common symptoms were hearing loss (100%), ear pain (85.7%), facial paralysis (42.8%), and tinnitus (42.8%). Imaging revealed tumor extension primarily to the temporal bone squamous part. Surgical strategies, including the single infratemporal fossa approach or combined infratemporal fossa approaches, achieved complete resection in all cases, with no recurrences during a median follow-up of 51 months.
CONCLUSIONS: Complete surgical resection with careful exposure is critical for minimizing recurrence. Our study highlights the efficacy of the single infratemporal fossa approach or combined infratemporal fossa approaches and emphasizes the need for further research into standardized staging and adjuvant therapies.