Colonic Diaphragm Disease Induced by Chronic Non-steroidal Anti-inflammatory Drug (NSAID)-Use Requiring Multiple Endoscopic Interventions: A Case Report.

Non-steroidal anti-inflammatory drug (NSAID)-induced colonic diaphragm disease is an uncommon yet significant cause of gastrointestinal symptoms. We present a case of a 51-year-old male with chronic NSAID use who developed abdominal pain, weight loss, and gastrointestinal bleeding. Imaging and endoscopy revealed a short, benign-appearing stricture in the ascending colon consistent with diaphragm disease. The patient required multiple endoscopic interventions, including lumen-apposing metal stent placement and balloon dilation, to relieve the obstruction. This case underscores the importance of recognizing NSAID-induced colonic pathology and highlights the role of advanced endoscopic techniques in managing complex strictures.