American journal of ophthalmology case reports · 2026
Bilateral myelin oligodendrocyte glycoprotein antibody-associated disease after cataract surgery.
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Besse Benjamin, Dos Santos Amélie, Mille Mathieu, Bobin Francois, Schultz Hugo, Berthomet Aline, Niemerich Léo, Muszalski Anna, Gianrocco Favia, Leveziel Nicolas
Аннотация
PURPOSE: To report an unusual presentation of bilateral myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) associated with optic neuritis occurring during the early post-operative cataract surgical period.
METHODS: This was an observational case report.
RESULTS: A 67-year-old Caucasian female presented with right eye visual acuity decrease occurring five days after bilateral cataract surgery. She also reported moderate pain associated with eye movements. While no inflammation could be observed, bilateral optic disc edema was observed on fundus examinations. Fluorescein angiography showed leakage of dye at late phases at the optic nerves, with no retinal vasculitis or choroidal ischemia on either eye. Orbit and brain magnetic resonance imaging showed bilateral optic perineuritis. Cerebrospinal fluid analysis was normal, as was the opening pressure (<25 cm of water) measured during lumbar puncture. Blood testing revealed MOGAD Immunoglobulin G (IgG) autoantibodies at a titer >1:100.
CONCLUSION: This report describes an atypical presentation of MOGAD associated with bilateral optic neuritis occurring a few days after cataract surgery.
METHODS: This was an observational case report.
RESULTS: A 67-year-old Caucasian female presented with right eye visual acuity decrease occurring five days after bilateral cataract surgery. She also reported moderate pain associated with eye movements. While no inflammation could be observed, bilateral optic disc edema was observed on fundus examinations. Fluorescein angiography showed leakage of dye at late phases at the optic nerves, with no retinal vasculitis or choroidal ischemia on either eye. Orbit and brain magnetic resonance imaging showed bilateral optic perineuritis. Cerebrospinal fluid analysis was normal, as was the opening pressure (<25 cm of water) measured during lumbar puncture. Blood testing revealed MOGAD Immunoglobulin G (IgG) autoantibodies at a titer >1:100.
CONCLUSION: This report describes an atypical presentation of MOGAD associated with bilateral optic neuritis occurring a few days after cataract surgery.