Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2018
Small Cell Neuroendocrine Carcinoma: A Rare Nasopharyngeal Malignancy with Aggressive Clinical Course.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Jia Siyu, Feng Zixing, Yan Xueqing, Zhang Zhiguo, Zhu Jingyan, Miao Di, Rao Jun, Shi Zhengjun, Ren Junli, Peng Feng
Аннотация
BACKGROUND: The evolution of metals and alloys in orthopedics has significantly improved the management of bone-related disorders, particularly osteoporosis, where decreased bone density and fragility complicate implant stability and healing. Traditional materials such as stainless steel and cobalt-chromium alloys provided strength and wear resistance but were associated with challenges like stress shielding and implant loosening.
MATERIALS AND METHODS: To address these limitations, titanium alloys emerged as a superior alternative due to their biocompatibility, lightweight nature, and bone-like elasticity, making them suitable for osteoporotic patients. Recent advancements have led to the development of magnesium-based biodegradable implants and nitinol (shape-memory alloy), which enable minimally invasive procedures and provide dynamic support. Additionally, porous and bioactive coatings, such as hydroxyapatite (HA), have been introduced to enhance osseointegration and implant fixation in compromised bone.
RESULTS: The integration of pharmacological strategies, such as bisphosphonates and sclerostin antibodies, with advanced implant surfaces has further enhanced bone regeneration. Emerging innovations, including 3D-printed personalized implants and smart alloys capable of adapting to physiological changes, show promise for improved long-term stability and faster recovery in osteoporotic patients.
CONCLUSION: The continuous development of orthopedic materials has paved the way for more effective treatments for osteoporosis, addressing key challenges such as implant stability, stress shielding, and bone regeneration. Innovations in bioactive coatings, biodegradable metals, and personalized implants represent the future of orthopedic care, offering improved outcomes for patients with compromised bone health. However, continuous research is essential to optimize these technologies for broader clinical applications.
MATERIALS AND METHODS: To address these limitations, titanium alloys emerged as a superior alternative due to their biocompatibility, lightweight nature, and bone-like elasticity, making them suitable for osteoporotic patients. Recent advancements have led to the development of magnesium-based biodegradable implants and nitinol (shape-memory alloy), which enable minimally invasive procedures and provide dynamic support. Additionally, porous and bioactive coatings, such as hydroxyapatite (HA), have been introduced to enhance osseointegration and implant fixation in compromised bone.
RESULTS: The integration of pharmacological strategies, such as bisphosphonates and sclerostin antibodies, with advanced implant surfaces has further enhanced bone regeneration. Emerging innovations, including 3D-printed personalized implants and smart alloys capable of adapting to physiological changes, show promise for improved long-term stability and faster recovery in osteoporotic patients.
CONCLUSION: The continuous development of orthopedic materials has paved the way for more effective treatments for osteoporosis, addressing key challenges such as implant stability, stress shielding, and bone regeneration. Innovations in bioactive coatings, biodegradable metals, and personalized implants represent the future of orthopedic care, offering improved outcomes for patients with compromised bone health. However, continuous research is essential to optimize these technologies for broader clinical applications.