Медицинская библиотека · medRxiv : the preprint server for health sciences · 2026

Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer's disease.

Chiotis Konstantinos, Blazhenets Ganna, Soleimani-Meigooni David N, Aisen Paul S, Amuiri Alinda, Atri Alireza, Beckett Laurel, Brickhouse Michael, Clark David G, Dage Jeffrey L, Day Gregory S, Duara Ranjan, Eloyan Ani, Foroud Tatiana, Graff-Radford Neill R, Grant Ian M, Hammers Dustin B, Honig Lawrence S, Johnson Erik C B, Jones David T, Kirby Kala, Koeppe Robert, Kramer Joel H, Kukull Walter A, Lagarde Julien, Leuzy Antoine, Maiti Piyush, Masdeu Joseph C, Mendez Mario F, Musiek Erik, Nudelman Kelly N, Onyike Chiadi U, Riddle Meghan, Rocha Salma, Rogalski Emily, Salloway Stephen, Schonhaut Daniel R, Sha Sharon, Shankar Ranjani, Taurone Alexander, Thangarajah Maryanne, Toga Arthur W, Touroutoglou Alexandra, Turner Raymond Scott, Vemuri Prashanthi, Wingo Thomas S, Wolk David A, Womack Kyle, Zhang Jiaxiuxiu, Carrillo Maria C, Dickerson Bradford C, Apostolova Liana G, La Joie Renaud, Rabinovici Gil D, Longitudinal Early-onset Alzheimer’s Disease Study consortium and the Alzheimer’s Disease Neuroimaging Initiative

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Аннотация

Early-onset Alzheimer's disease (EOAD) and Late-onset AD (LOAD) differ in clinical presentations and rates of progression. We aimed to compare baseline and longitudinal tau PET burden, and their relationship with clinical variables in amyloid-PET positive, cognitively impaired participants from the Longitudinal Early-Onset Alzheimer's Disease Study (EOAD; n=390) and Alzheimer's Disease Neuroimaging Initiative (LOAD; n=211). Patients with EOAD showed higher baseline tau PET retention, broader neuroanatomical involvement and faster accumulation rates over time compared to LOAD, after adjusting for amyloid load and clinical stage. Tau PET showed stronger correlations with baseline amyloid burden and clinical measures of global cognition and function in EOAD than LOAD. We conclude that earlier age of onset in AD is linked to a more aggressive tauopathy, which in turn is a primary driver of clinical decline. These findings suggest that optimal therapeutic targets and strategies may differ between EOAD and LOAD.

Для цитирования: Chiotis Konstantinos, Blazhenets Ganna, Soleimani-Meigooni David N, Aisen Paul S, Amuiri Alinda, Atri Alireza, Beckett Laurel, Brickhouse Michael, Clark David G, Dage Jeffrey L, Day Gregory S, Duara Ranjan, Eloyan Ani, Foroud Tatiana, Graff-Radford Neill R, Grant Ian M, Hammers Dustin B, Honig Lawrence S, Johnson Erik C B, Jones David T, Kirby Kala, Koeppe Robert, Kramer Joel H, Kukull Walter A, Lagarde Julien, Leuzy Antoine, Maiti Piyush, Masdeu Joseph C, Mendez Mario F, Musiek Erik, Nudelman Kelly N, Onyike Chiadi U, Riddle Meghan, Rocha Salma, Rogalski Emily, Salloway Stephen, Schonhaut Daniel R, Sha Sharon, Shankar Ranjani, Taurone Alexander, Thangarajah Maryanne, Toga Arthur W, Touroutoglou Alexandra, Turner Raymond Scott, Vemuri Prashanthi, Wingo Thomas S, Wolk David A, Womack Kyle, Zhang Jiaxiuxiu, Carrillo Maria C, Dickerson Bradford C, Apostolova Liana G, La Joie Renaud, Rabinovici Gil D, Longitudinal Early-onset Alzheimer’s Disease Study consortium and the Alzheimer’s Disease Neuroimaging Initiative. Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer's disease.. medRxiv : the preprint server for health sciences. 2026. DOI: 10.64898/2026.01.25.26344738.

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