The inflammation-nutrition axis and survival outcomes: Role of the neutrophil percentage-to-albumin ratio in patients with sleep disorders.

BackgroundThe neutrophil percentage-to-albumin ratio has shown prognostic significance across several chronic diseases; however, its relevance within the context of sleep disorders has not been investigated.MethodsThis study utilized data from the National Health and Nutrition Examination Survey for the years 2005-2014 to explore the connection between the neutrophil percentage-to-albumin ratio and all-cause mortality in people with sleep disorders. Mortality risk was assessed using Cox regression, and the analyses included restricted cubic spline, Kaplan-Meier survival, subgroup, and time-dependent receiver operating characteristic curve analyses.ResultsA positive correlation was identified between the neutrophil percentage-to-albumin ratio and mortality risk among individuals with sleep disorders (hazard ratio = 1.09, 95% confidence interval: 1.05, 1.14). A comparison between the highest (Q4) and lowest (Q1) quartiles revealed that patients in Q4 had an 86% higher mortality risk (hazard ratio = 1.86, 95% confidence interval: 1.31, 2.65). Subgroup analysis further confirmed consistency across different demographic and clinical strata (all p for interaction > 0.05). Furthermore, the neutrophil percentage-to-albumin ratio demonstrated strong predictive performance for early mortality risk in patients with sleep disorders (1-year area under the curve = 0.751, 95% confidence interval: 0.693, 0.808).ConclusionsAmong patients diagnosed with sleep disorders, higher levels of NPAR are independently linked to an elevated risk of all-cause mortality.