Translational gastroenterology and hepatology · 2026
Integrated care management model for liver transplantation: a narrative review and single-center implementation experience.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Deng Ying, Cai Yunshi, Lyu Tao, Yang Jian, Xu Gang, Zhou Yongzhao, Yang Zhengting, Chai Qi, Yang Jiayin, Xie Kunlin, Wu Hong
Аннотация
BACKGROUND AND OBJECTIVE: Liver transplantation (LT) is the most effective end-stage liver disease (ESLD) therapeutic intervention. However, in China, many liver transplant recipients lack a comprehensive management approach. This narrative review summarizes the current deficiencies in long-term post-transplant care and proposes a comprehensive model for Integrated Care Management (ICM) aimed at improving long-term outcomes after LT.
METHODS: An extensive electronic literature search was performed using PubMed database to identify relevant articles. The search included prospective clinical trials, observational trials, case-control studies, systematic reviews with or without meta-analysis. Articles were limited to English and Chinese language publications. The following Medical Subject Headings (MeSH) terms and free-text keywords were combined with Boolean operators: ("liver transplantation" OR "liver transplant*" OR "orthotopic liver transplantation" OR "OLT") AND ("postoperative management" OR "whole-course management" OR "perioperative care" OR "long-term follow-up") AND ("immunosuppress*" OR "tacrolimus" OR "cyclosporine" OR "mycophenolate" OR "infection prophylaxis" OR "graft function" OR "rejection" OR "biliary stricture" OR "hepatic artery thrombosis" OR "renal dysfunction" OR "hepatitis B recurrence" OR "hepatitis C recurrence").
KEY CONTENT AND FINDINGS: Research has shown the global number of LT recipients continues to rise, affecting millions of individuals and placing a substantial burden on healthcare systems worldwide. Despite considerable progress over the past three decades in surgical techniques, perioperative care, and immunosuppressive therapy, long-term post-transplant management has received comparatively limited attention from both the public and policy-makers. This neglect has contributed to suboptimal long-term outcomes, including increased mortality and reduced quality of life among recipients.
CONCLUSIONS: A comprehensive model for ICM may be a new direction to improve the long-term outcomes after LT in the future.
METHODS: An extensive electronic literature search was performed using PubMed database to identify relevant articles. The search included prospective clinical trials, observational trials, case-control studies, systematic reviews with or without meta-analysis. Articles were limited to English and Chinese language publications. The following Medical Subject Headings (MeSH) terms and free-text keywords were combined with Boolean operators: ("liver transplantation" OR "liver transplant*" OR "orthotopic liver transplantation" OR "OLT") AND ("postoperative management" OR "whole-course management" OR "perioperative care" OR "long-term follow-up") AND ("immunosuppress*" OR "tacrolimus" OR "cyclosporine" OR "mycophenolate" OR "infection prophylaxis" OR "graft function" OR "rejection" OR "biliary stricture" OR "hepatic artery thrombosis" OR "renal dysfunction" OR "hepatitis B recurrence" OR "hepatitis C recurrence").
KEY CONTENT AND FINDINGS: Research has shown the global number of LT recipients continues to rise, affecting millions of individuals and placing a substantial burden on healthcare systems worldwide. Despite considerable progress over the past three decades in surgical techniques, perioperative care, and immunosuppressive therapy, long-term post-transplant management has received comparatively limited attention from both the public and policy-makers. This neglect has contributed to suboptimal long-term outcomes, including increased mortality and reduced quality of life among recipients.
CONCLUSIONS: A comprehensive model for ICM may be a new direction to improve the long-term outcomes after LT in the future.