[Recurrence in patients diagnosed with acne treated by isotretinoin and other methods].

Common acne is the most frequently diagnosed dermatosis at the age of adolescence. It may lead to psychic disturbances and/or even depression as a result of its distinctly visible localization, very long-lasting symptoms, in sequela numerous deforming scars or vicious cicatrices. The objective of the present paper is to assess recurrences after the treatment of severe acne forms in patients treated in the Department of Dermatology in the years 1991-2000, with administration of various medications applied locally and/or generally. The evaluation of treatment results determined the highest, statistically significant difference between the patients subjected to isotretinoin-supported treatment process and the locally cured patients. In the group of locally treated patients the rate of the acne symptoms recurrence could be observed more often. In the remaining groups of patients, no statistically significant differences were reported. A little higher acne symptoms recurrence rate is apparent in the group of patients locally treated, as compared with that subjected to antibiotics-supported therapy. A statistically significant relationship between the therapy duration with the application of individual methods and the recurrence of illness has not been proven as yet. The value of p = 0,5245 proved that there existed no relationship between the diagnosis and a period of time elapsed--at the end of therapy--since the recurrence of acne disorders has been observed. The longest period of remission lasted when inversed acne had been recognized. Recurrence of the disease was observed the most rapidly in patients affected with acne conglobata. When examining the relationship between the duration of acne symptoms recurrence vs. treatment process, statistically significant differences amongst the individual applied methods were recorded. In the group A, recurrence of illness occurred at a higher rate. A statistically significant relationship between the recurrence of signs and symptoms and the initial diagnosis was excluded. A higher percentage of recurrence in the groups I, II and III has been reported as compared with group V. There is a certain relationship between the patient's age and the recurrence of the disease. It mainly referred to the elderly. Statistical analysis has proved that there existed significant relationship between the recurrence of the disease analysed and the patients' sex. A little higher rate of illness occurrence can be observed in a female group. The study revealed that recurrences in group of patients treated by locally active preparations were observed usually 6 months after the end of therapy.