A dual-mechanism injectable hydrogel integrating reactive oxygen species regulationand low-level laser therapy for androgenetic alopecia remediation.

Androgenetic Alopecia (AGA) is a chronic disease characterized by follicular degenerative changes and the continuous deterioration of the follicular microenvironment. Excessive accumulation of reactive oxygen species (ROS) and insufficient local microcirculation are both critical factors contributing to the onset and progression of this disease. However, existing clinical treatment approaches are mostly confined to single-target interventions for AGA. Herein, a multifunctional hydrogel system that integrates multi-active nanozymes with melanin nano photothermal agents was designed for efficient multimodal synergistic treatment of AGA. Owing to the existence of dynamic covalent bonds, such multifunctional hydrogel exhibits favorable injectability and tissue adhesion capability, facilitating the precise and sustained release of nanodrugs. Among them, multi-active nanozymes can mimic the activities of superoxide dismutase (SOD) and catalase (CAT), enabling efficient cascade clearance of reactive oxygen species such as superoxide anions (·O2-) and hydrogen peroxide (H2O2) at the lesion site, thereby restoring the redox homeostasis of hair follicles. Additionally, the low-temperature photothermal effect exerted by melanin nano photothermal agents under infrared laser irradiation can effectively stimulate hair follicle cells, enhance follicular metabolic activity, and improve local microcirculation in the hair area. Through the synergistic effects of ROS scavenging, low-level photothermal stimulation, and microcirculation regulation, this multifunctional hydrogel system holds promise for fundamentally improving the follicular microenvironment, promoting healthy hair growth, and thus achieving multi-target precision therapy for AGA.