Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
Assessment of myocardial sympathetic innervation with [123I]mIBG myocardial scintigraphy: A comparative study between an Anger and a ring-configured cadmium-zinc-telluride gamma camera.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Hagerman Jessica, Engblom Shahnaz Akil, Andelius Irma Cerić, Stenvall Anna, Minarik David, Hall Sara, Stomrud Erik, Nahimi Adjmal, Smith Ruben, Hansson Oskar, Hedeer Fredrik
Аннотация
BACKGROUND: Assessment of myocardial sympathetic innervation with iodine-123-metaiodobenzylguanidine ([123I]mIBG) scintigraphy is conventionally performed by determining the heart-to-mediastinum ratio (HMR) on planar images. This study aimed to investigate the feasibility of determining HMR from reprojected [123I]mIBG planar images derived from tomographic data by a ring-configured cadmium-zinc-telluride (CZT) gamma camera and its agreement with HMR determined from [123I]mIBG planar images by an Anger gamma camera, in the assessment of myocardial sympathetic innervation.
METHODS: A total of 105 study participants (suspected idiopathic rapid-eye-movement sleep behavior disorder n = 55, early-stage Parkinson's Disease n = 36, and healthy controls n = 14) who were referred for [123I]mIBG myocardial scintigraphy were included, in addition to eight phantom experiments simulating a range of HMR. HMR was determined from planar and reprojected planar images acquired with an Anger gamma camera and a ring-configured CZT gamma camera, respectively, for all study participants and phantom experiments. Agreement in HMR between the two imaging methods was analyzed in Bland-Altman plots. Intra- and interobserver variability was evaluated for both imaging methods in a subset of images.
RESULTS: The agreement between planar and reprojected planar images was good, with a mean difference in HMR of 0.11 (95% limits of agreement -0.16 to 0.38) for the study participants. Intra- and interobserver variability was low and comparable for both imaging methods. Results from the phantom experiments were consistent with those from the study participants.
CONCLUSIONS: Determining HMR from reprojected [123I]mIBG myocardial scintigraphy planar images acquired with a ring-configured CZT gamma camera is feasible and shows good agreement with HMR determined from planar images by a conventional Anger gamma camera.
METHODS: A total of 105 study participants (suspected idiopathic rapid-eye-movement sleep behavior disorder n = 55, early-stage Parkinson's Disease n = 36, and healthy controls n = 14) who were referred for [123I]mIBG myocardial scintigraphy were included, in addition to eight phantom experiments simulating a range of HMR. HMR was determined from planar and reprojected planar images acquired with an Anger gamma camera and a ring-configured CZT gamma camera, respectively, for all study participants and phantom experiments. Agreement in HMR between the two imaging methods was analyzed in Bland-Altman plots. Intra- and interobserver variability was evaluated for both imaging methods in a subset of images.
RESULTS: The agreement between planar and reprojected planar images was good, with a mean difference in HMR of 0.11 (95% limits of agreement -0.16 to 0.38) for the study participants. Intra- and interobserver variability was low and comparable for both imaging methods. Results from the phantom experiments were consistent with those from the study participants.
CONCLUSIONS: Determining HMR from reprojected [123I]mIBG myocardial scintigraphy planar images acquired with a ring-configured CZT gamma camera is feasible and shows good agreement with HMR determined from planar images by a conventional Anger gamma camera.
Предметные рубрики MeSH
Humans3-IodobenzylguanidineGamma CamerasMaleTelluriumZincFemaleCadmiumMiddle AgedHeartAgedPhantoms, ImagingRadiopharmaceuticalsSympathetic Nervous SystemParkinson DiseaseAdultMyocardial Perfusion ImagingReproducibility of ResultsREM Sleep Behavior DisorderRadionuclide ImagingFeasibility StudiesMediastinum