Adult intussusception caused by solitary intestinal Peutz-Jeghers polyp mimicking a malignant colon cancer.

Adult intussusception is rare, accounting for ~1% of intestinal obstruction cases, and most cases are caused by neoplastic lesions. This report describes a 30-year-old male patient with a solitary Peutz-Jeghers syndrome hamartomatous polyp that mimicked colon cancer preoperatively. The patient had no mucocutaneous pigmentation, family history of polyposis or malignancy, and no STK11/LKB1 mutation. Whole-exome sequencing identified two novel heterozygous variants in POLE and EXO1. Intraoperative exploration of the terminal ileum is critical to avoid misdiagnosis and unnecessary colectomy.