Journal of pediatric gastroenterology and nutrition · 2024
Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Homan Matjaž, Thomson Mike, Bontems Patrick, Saccomani Marco Deganello, Dias Jorge Amil, Faraci Simona, Furlano Raoul, Hojsak Iva, Ledder Oren, Slae Mordechai, Narula Priya, Nita Andreia Florina, Norsa Lorenzo, Oliva Salvatore, Papadopoulou Alexandra, Romano Claudio, Rybak Anna, Spyropoulou Vasiliki, Tambucci Renato, Tzivinikos Christos, van Wijk Michiel, Borrelli Osvaldo, Endoscopy SIG and Motility SIG of ESPGHAN Organisation
Аннотация
WHAT IS KNOWN: Botulinum toxin (BoNT) causes muscle relaxation by inhibiting acetylcholine release from presynaptic motor neurons at the neuromuscular junction.
WHAT IS NEW: In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes. BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying. Anal achalasia and constipation after Hirschsprung disease corrective surgery are very promising indications for BoNT use. In selected children with resistant type of functional constipation and chronic anal fissure, BoNT is a viable option for treating.
WHAT IS NEW: In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes. BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying. Anal achalasia and constipation after Hirschsprung disease corrective surgery are very promising indications for BoNT use. In selected children with resistant type of functional constipation and chronic anal fissure, BoNT is a viable option for treating.