Malaria journal · 2018

Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group.

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Thriemer Kamala, Bobogare Albino, Ley Benedikt, Gudo Clarice Samo, Alam Mohammad Shafiul, Anstey Nick M, Ashley Elizabeth, Baird J Kevin, Gryseels Charlotte, Jambert Elodie, Lacerda Marcus, Laihad Ferdinand, Marfurt Jutta, Pasaribu Ayodhia Pitaloka, Poespoprodjo Jeanne Rini, Sutanto Inge, Taylor Walter R, van den Boogaard Christel, Battle Katherine E, Dysoley Lek, Ghimire Prakash, Hawley Bill, Hwang Jimee, Khan Wasif Ali, Mudin Rose Nani Binti, Sumiwi Maria Endang, Ahmed Rukhsana, Aktaruzzaman M M, Awasthi Kiran Raj, Bardaji Azucena, Bell David, Boaz Leonard, Burdam Faustina Helen, Chandramohan Daniel, Cheng Qin, Chindawongsa Keobouphaphone, Culpepper Janice, Das Santasabuj, Deray Raffy, Desai Meghna, Domingo Gonzalo, Duoquan Wang, Duparc Stephan, Floranita Rustini, Gerth-Guyette Emily, Howes Rosalind E, Hugo Cecilia, Jagoe George, Sariwati Elvieda, Jhora Sanya Tahmina, Jinwei Wu, Karunajeewa Harin, Kenangalem Enny, Lal Bibek Kumar, Landuwulang Chandra, Le Perru Emmanuel, Lee Sang-Eun, Makita Leo Sora, McCarthy James, Mekuria Asrat, Mishra Neelima, Naket Esau, Nambanya Simone, Nausien Johnny, Duc Thang Ngo, Thi Thuan Nguyen, Noviyanti Rinitis, Pfeffer Daniel, Qi Gao, Rahmalia Annisa, Rogerson Stephen, Samad Iriani, Sattabongkot Jetsumon, Satyagraha Ari, Shanks Dennis, Sharma Surender Nath, Sibley Carol Hopkins, Sungkar Ali, Syafruddin Din, Talukdar Arunansu, Tarning Joel, Ter Kuile Feiko, Thapa Suman, Theodora Minerva, Huy Tho Tran, Waramin Edward, Waramori Govert, Woyessa Adugna, Wongsrichanalai Chansuda, Xa Nguyen Xuan, Yeom Joon Sup, Hermawan Lukas, Devine Angela, Nowak Spike, Jaya Indra, Supargiyono Supargiyono, Grietens Koen Peeters, Price Ric N

Аннотация

The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.

Предметные рубрики MeSH

Antimalarials Asia Humans Malaria, Vivax Pacific Islands Plasmodium vivax Primaquine Treatment Adherence and Compliance Treatment Outcome

Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group.

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Аннотация

Предметные рубрики MeSH