Journal of global antimicrobial resistance · 2025
Emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China.
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Kong Ximei, Wang Jian, Lei Gaopeng, Yang Yang, Huang Weifeng, Leng Yun, Miao Yanfang, Li Ming, Yuan Qiwu, Zhao Yuanyuan, Xu Xin, Zuo Haojiang, Tian Lvbo
Аннотация
OBJECTIVES: The study aimed to investigate the prevalence, antimicrobial resistance profiles, and virulence characteristics of Salmonella isolates from clinical cases in Sichuan, China, collected from 2019 to 2021.
METHODS: A total of 153 Salmonella isolates from 19 regions in Sichuan Province were analysed. Sequence types (STs) were identified using multi-locus sequence typing. Antimicrobial susceptibility testing was conducted to assess resistance profiles, while whole-genome sequencing was used to detect antimicrobial resistance genes (ARGs) and virulence genes.
RESULTS: Among the 153 Salmonella isolates, 49 STs were identified. ST11 (S. Enteritidis) was the most prevalent, while S. Kentucky comprised 3.27% (5/153) of isolates, significantly higher than the national average (0.33%, P < 0.05). All S. Kentucky ST198 isolates were extensively drug-resistant, exhibiting resistance to at least seven antimicrobial classes, including fluoroquinolones and extended-spectrum cephalosporins. S. Kentucky ST198 harboured significantly more ARGs (P < 0.001) and virulence genes (P < 0.001) than other strains. ARGs such as CTX-M-55, TEM-216, TEM-90, and TEM-150 were significantly more prevalent (P < 0.05), conferring resistance to extended-spectrum cephalosporins and β-lactams. Additionally, the absence of sifA (16.7% vs. 91.8%, P < 0.001) and shdA (0.0% vs. 68.7%, P = 0.001), suggesting that these genes may influence the reduced risk of human infection by ST198.
CONCLUSIONS: These findings highlight the emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China and underscore the urgent need for ongoing surveillance in this region due to its significant public health impact.
METHODS: A total of 153 Salmonella isolates from 19 regions in Sichuan Province were analysed. Sequence types (STs) were identified using multi-locus sequence typing. Antimicrobial susceptibility testing was conducted to assess resistance profiles, while whole-genome sequencing was used to detect antimicrobial resistance genes (ARGs) and virulence genes.
RESULTS: Among the 153 Salmonella isolates, 49 STs were identified. ST11 (S. Enteritidis) was the most prevalent, while S. Kentucky comprised 3.27% (5/153) of isolates, significantly higher than the national average (0.33%, P < 0.05). All S. Kentucky ST198 isolates were extensively drug-resistant, exhibiting resistance to at least seven antimicrobial classes, including fluoroquinolones and extended-spectrum cephalosporins. S. Kentucky ST198 harboured significantly more ARGs (P < 0.001) and virulence genes (P < 0.001) than other strains. ARGs such as CTX-M-55, TEM-216, TEM-90, and TEM-150 were significantly more prevalent (P < 0.05), conferring resistance to extended-spectrum cephalosporins and β-lactams. Additionally, the absence of sifA (16.7% vs. 91.8%, P < 0.001) and shdA (0.0% vs. 68.7%, P = 0.001), suggesting that these genes may influence the reduced risk of human infection by ST198.
CONCLUSIONS: These findings highlight the emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China and underscore the urgent need for ongoing surveillance in this region due to its significant public health impact.