Therapeutic advances in neurological disorders · 2026
Objective tremor monitoring using tri-axis accelerometer in MRgFUS thalamotomy for essential tremor: a feasibility study.
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Liu Kai-Chun, Macerollo Antonella, Heng Hoon-Ming, Chen Pei-Chiang, Lu Ming-Kuei, Chen Chun Ming, Tsai Chon-Haw, Chen Jui-Cheng
Аннотация
BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy has shown promising results in treating pharmaco-resistant essential tremor (ET). This incisionless, image-guided technique targets the ventralis intermedius nucleus of the thalamus with precision, sparing surrounding eloquent tissue.Objective: This study aims to assess the efficacy of MRgFUS thalamotomy in improving tremor among ET patients, as objectively measured by a tri-axis accelerometer, and to compare these objective measures with the conventional Clinical Rating Scale for Tremor (CRST).Design: Prospective observational study.
METHODS: Ten ET patients (aged 68.1 ± 11.8 years) received the MRgFUS treatment. Improvements in tremor severity were assessed using primary (CRST), with additional measurements of kinematic feature obtained from a tri-axis accelerometer. Correlations between accelerometer-derived kinematic features and CRST scores were evaluated.
RESULTS: Significant improvement in tremor severity was observed in the cohort, as measured by both the accelerometer and CRST (paired Student's t test, p < 0.05) before and 1 day after the treatment. A moderate-to-strong correlation was found between accelerometer measurements and CRST scores.
CONCLUSION: The tri-axis accelerometer provides an effective means of monitoring tremor reduction following MRgFUS and correlated well to the clinical scales like CRST. This study supports the feasibility of accelerometer-based monitoring in clinical practice for MRgFUS assessment.
METHODS: Ten ET patients (aged 68.1 ± 11.8 years) received the MRgFUS treatment. Improvements in tremor severity were assessed using primary (CRST), with additional measurements of kinematic feature obtained from a tri-axis accelerometer. Correlations between accelerometer-derived kinematic features and CRST scores were evaluated.
RESULTS: Significant improvement in tremor severity was observed in the cohort, as measured by both the accelerometer and CRST (paired Student's t test, p < 0.05) before and 1 day after the treatment. A moderate-to-strong correlation was found between accelerometer measurements and CRST scores.
CONCLUSION: The tri-axis accelerometer provides an effective means of monitoring tremor reduction following MRgFUS and correlated well to the clinical scales like CRST. This study supports the feasibility of accelerometer-based monitoring in clinical practice for MRgFUS assessment.