Explore (New York, N.Y.) · 2026
Intraoperative electroacupuncture alleviates angina and attenuates periprocedural myocardial injury in patients undergoing percutaneous coronary intervention.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Liang Yu-Peng, Zhang Yun-Shun-Zi, Zhang Ai-Meng, Li Shao-Hui, Huang Jun-Teng, Ai Chang-Jiang, Peng Se, Jiang Xiao, Zhang He-Zhen, Lai Tian-Wei, Su Guo-Zhu, Wang Kai-Li, Li Rong, Li Chuang-Peng, Liu Pei-Zhong
Аннотация
BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) frequently experience intraoperative angina and periprocedural myocardial injury (PMI), conditions associated with adverse clinical outcomes. Electroacupuncture (EA) demonstrated promising potential in analgesia and cardioprotection. This study aimed to evaluate the efficacy and safety of intraoperative EA in mitigating angina, attenuating PMI, and modulating the systemic inflammatory response in patients undergoing PCI.
METHODS: A total of 120 patients with angina pectoris undergoing percutaneous coronary intervention (PCI) were enrolled and randomly assigned to either an EA group (n = 60) or a sham-EA group (n = 60). The EA group received continuous intraoperative electrical stimulation at acupoints Neiguan (PC6) and Ximen (PC4), whereas the sham-EA group received sham intervention at non-acupoints. Evaluated outcomes included intraoperative angina severity assessed by the Visual Analogue Scale (VAS), the extent of myocardial injury determined by high-sensitivity cardiac troponin T (hs-cTnT) and CK-MB levels at 24 h post-PCI, levels of inflammatory biomarkers (TNF-α, IL-6, hs-CRP, IL-1β), and the incidence of adverse events.
RESULTS: Patients in the EA group reported significantly lower intraoperative angina scores (VAS) compared to the sham-EA group (P < 0.001). Consistent with this symptomatic relief, the EA group demonstrated attenuated myocardial injury, evidenced by significantly lower hs-cTnT levels at 24 h post-PCI (median [IQR]: 25.27 [11.54, 108.65] vs. 35.37 [14.35, 237.25]; P = 0.042), whereas no significant difference was observed in CK-MB levels (P = 0.243). In terms of inflammatory response, concentrations of TNF-α and IL-6 were significantly lower in the EA group (P < 0.05 for both), while no significant inter-group differences were found for hs-CRP and IL-1β. The incidence of adverse events was comparable between the two groups (P > 0.05).
CONCLUSION: Intraoperative electroacupuncture (EA) is a feasible and safe adjunctive strategy for effectively alleviating angina and potentially attenuating myocardial injury in patients undergoing PCI. These beneficial effects may be mediated through the modulation of inflammatory responses. However, given the preliminary nature of these findings, further validation in large-scale, multi-center trials is warranted.
METHODS: A total of 120 patients with angina pectoris undergoing percutaneous coronary intervention (PCI) were enrolled and randomly assigned to either an EA group (n = 60) or a sham-EA group (n = 60). The EA group received continuous intraoperative electrical stimulation at acupoints Neiguan (PC6) and Ximen (PC4), whereas the sham-EA group received sham intervention at non-acupoints. Evaluated outcomes included intraoperative angina severity assessed by the Visual Analogue Scale (VAS), the extent of myocardial injury determined by high-sensitivity cardiac troponin T (hs-cTnT) and CK-MB levels at 24 h post-PCI, levels of inflammatory biomarkers (TNF-α, IL-6, hs-CRP, IL-1β), and the incidence of adverse events.
RESULTS: Patients in the EA group reported significantly lower intraoperative angina scores (VAS) compared to the sham-EA group (P < 0.001). Consistent with this symptomatic relief, the EA group demonstrated attenuated myocardial injury, evidenced by significantly lower hs-cTnT levels at 24 h post-PCI (median [IQR]: 25.27 [11.54, 108.65] vs. 35.37 [14.35, 237.25]; P = 0.042), whereas no significant difference was observed in CK-MB levels (P = 0.243). In terms of inflammatory response, concentrations of TNF-α and IL-6 were significantly lower in the EA group (P < 0.05 for both), while no significant inter-group differences were found for hs-CRP and IL-1β. The incidence of adverse events was comparable between the two groups (P > 0.05).
CONCLUSION: Intraoperative electroacupuncture (EA) is a feasible and safe adjunctive strategy for effectively alleviating angina and potentially attenuating myocardial injury in patients undergoing PCI. These beneficial effects may be mediated through the modulation of inflammatory responses. However, given the preliminary nature of these findings, further validation in large-scale, multi-center trials is warranted.