Unraveling the Complexity of Non-typhoidal Salmonella Genitourinary Infection in HIV: A Case Report and Management Strategy.

Salmonella urinary tract infections (UTIs) are rare and typically affect immunocompromised or anatomically predisposed individuals. While usually foodborne, transmission can also occur from pets or person to person. Symptoms mimic common UTIs and may present with or without prior gastrointestinal illness. We report the case of a 56-year-old HIV-positive male with poor medication compliance who presented with altered mental status and burning micturition. Urine and blood cultures revealed non-typhoidal Salmonella, prompting targeted antibiotic therapy. Treatment involves at least 14 days of antibiotics, with repeat urine cultures to ensure eradication. Rising antibiotic resistance necessitates awareness of local sensitivity patterns.