Multiple regulatory roles of UNC93B1 in innate immunity.

Uncoordinated 93 homolog B1 (UNC93B1) is a key innate immune regulator that affects the function of pattern recognition receptors. UNC93B1 is responsible for governing the intracellular trafficking and activation of nucleic acid-sensing TLRs. Recently, UNC93B1 was shown to regulate the cGAS/STING signaling pathway. As a result, UNC93B1 is a promising therapeutic target for various human diseases. In this review, we provide an update on new findings establishing the regulatory role of UNC93B1 in innate immunity, including the antibacterial activity of neutrophils, the PRR-mediated signaling pathway, and its specific role in autoimmune illnesses and severe viral infectious diseases. A thorough assessment of the role of UNC93B1 in innate immune regulation will allow us to identify possible novel therapeutic targets in UNC93B1-associated disorders.