Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Structural retinal and choroidal changes in keratoconus: A cross-sectional OCT study stratified by ABCD grading.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Mohammed Marrwan Hisham, Hashemian Hesam, Jadidi Khosrow, Naroo Shehzad A, Ambrósio Renato, Aghamolaei Hossein, Nejat Farhad, Naseri Milad, Narooie-Noori Foroozan, Khorrami-Nejad Masoud
Аннотация
PURPOSE: To evaluate posterior segment structural changes in patients with keratoconus (KC), and to assess their association with anterior segment parameters across disease severity stages using the ABCD classification system.
METHODS: This cross-sectional observational study graded staged KC severity I-IV based on the ABCD grading system. All participants underwent comprehensive ophthalmic evaluation, including corneal tomography (Pentacam HR), optical coherence tomography with enhanced depth imaging (Spectralis EDI-OCT), and ocular biometry. Posterior segment parameters were compared across KC stages and with controls. Correlation analyses were performed to assess associations between anterior and posterior segment metrics.
RESULTS: The study included 124 eyes from 124 patients with keratoconus and 32 right eyes from healthy control individuals. RNFL thickness was significantly reduced in KC eyes compared to controls (103.7 ± 11.6 μm vs. 110.0 ± 12.0 μm; P = 0.008), with a progressive decline observed from stage I to IV. Central foveal retinal thickness showed a mild, non-significant reduction in stages III and IV (234.6 ± 20.9 μm and 232.8 ± 19.7 μm, respectively) compared to earlier stages and controls (P = 0.066). SFCT remained relatively unchanged across all KC stages and between KC and control groups (416.6 ± 85.4 μm vs. 420.3 ± 70.2 μm; P = 0.824). Correlation analyses revealed no significant associations between anterior segment parameters (e.g., apex pachymetry, thinnest corneal thickness) and posterior segment measurements (P > 0.05 for all).
CONCLUSION: KC is associated with significant RNFL thinning, particularly in advanced stages, suggesting posterior segment involvement. However, retinal and choroidal thicknesses remain largely unaffected.
METHODS: This cross-sectional observational study graded staged KC severity I-IV based on the ABCD grading system. All participants underwent comprehensive ophthalmic evaluation, including corneal tomography (Pentacam HR), optical coherence tomography with enhanced depth imaging (Spectralis EDI-OCT), and ocular biometry. Posterior segment parameters were compared across KC stages and with controls. Correlation analyses were performed to assess associations between anterior and posterior segment metrics.
RESULTS: The study included 124 eyes from 124 patients with keratoconus and 32 right eyes from healthy control individuals. RNFL thickness was significantly reduced in KC eyes compared to controls (103.7 ± 11.6 μm vs. 110.0 ± 12.0 μm; P = 0.008), with a progressive decline observed from stage I to IV. Central foveal retinal thickness showed a mild, non-significant reduction in stages III and IV (234.6 ± 20.9 μm and 232.8 ± 19.7 μm, respectively) compared to earlier stages and controls (P = 0.066). SFCT remained relatively unchanged across all KC stages and between KC and control groups (416.6 ± 85.4 μm vs. 420.3 ± 70.2 μm; P = 0.824). Correlation analyses revealed no significant associations between anterior segment parameters (e.g., apex pachymetry, thinnest corneal thickness) and posterior segment measurements (P > 0.05 for all).
CONCLUSION: KC is associated with significant RNFL thinning, particularly in advanced stages, suggesting posterior segment involvement. However, retinal and choroidal thicknesses remain largely unaffected.