Movement disorders : official journal of the Movement Disorder Society · 2023
Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2.
СтатьяНазвание и аннотация: Перевод в очереди
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Rezende Filho Flávio Moura, Jurkute Neringa, de Andrade João Brainer Clares, Marianelli Bruna Ferraço, de Lima Fabrício Diniz, França Marcondes Cavalcante, Sallum Juliana Maria Ferraz, Yu-Wai-Man Patrick, Barsottini Orlando G P, Pedroso José Luiz
Аннотация
BACKGROUND: ATXN2 is the causative gene of spinocerebellar ataxia type 2 (SCA2) and has been implicated in glaucoma pathogenesis. Therefore, studying ocular changes in SCA2 could uncover clinically relevant changes.
OBJECTIVE: The aim was to investigate optic disc and retinal architecture in SCA2.
METHODS: We evaluated 14 patients with SCA2 and 26 controls who underwent intraocular pressure measurement, fundoscopy, and macular and peripapillary spectral domain optical coherence tomography (SD-OCT). We compared SD-OCT measurements in SCA2 and controls, and the frequency of glaucomatous changes among SCA2, controls, and 76 patients with other SCAs (types 1, 3, 6, and 7).
RESULTS: The macula, peripapillary retinal nerve fiber and inner plexiform layers were thinner in SCA2 than in controls. Increased cup-to-disc ratio was more frequent in SCA2 than in controls and other SCAs.
CONCLUSIONS: Ocular changes are part of SCA2 phenotype. Future studies should further investigate retinal and optic nerve architecture in this disorder.
OBJECTIVE: The aim was to investigate optic disc and retinal architecture in SCA2.
METHODS: We evaluated 14 patients with SCA2 and 26 controls who underwent intraocular pressure measurement, fundoscopy, and macular and peripapillary spectral domain optical coherence tomography (SD-OCT). We compared SD-OCT measurements in SCA2 and controls, and the frequency of glaucomatous changes among SCA2, controls, and 76 patients with other SCAs (types 1, 3, 6, and 7).
RESULTS: The macula, peripapillary retinal nerve fiber and inner plexiform layers were thinner in SCA2 than in controls. Increased cup-to-disc ratio was more frequent in SCA2 than in controls and other SCAs.
CONCLUSIONS: Ocular changes are part of SCA2 phenotype. Future studies should further investigate retinal and optic nerve architecture in this disorder.