Regenerative medicine · 2025
Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Oliver Dulic, Dzihan Abazovic, Mirko Obradovic, Miodrag Vranjes, Ivica Lalic, Srdjan Ninkovic, Predrag Rasovic, Mile Bjelobrk, Branko Baljak, Milan Milinkov, Milan Tosic, Srdjan Sarac
Аннотация
AIM: To evaluate the effectiveness of a bioregenerative scaffold created from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin in treating complicated non-unions of the supracondylar femur, humeral shaft, and radius and ulna.
METHODS & MATERIALS: Three patients with non-unions resulting from multiple surgical failures underwent bone stabilization along with the application of a novel bioregenerative scaffold. X-rays and subjective assessments were collected prior to surgery and at 6- and 12-months post-surgery.
RESULTS: All non-unions demonstrated healing with adequate callus formation, as confirmed by radiological assessments. By 12 months, all patients were able to resume full weight-bearing activities or regain full range of motion and physical strength without pain. Statistical analysis revealed improvements across all assessment scales compared to pre-surgical values.
CONCLUSION: This approach offers a viable option for treating complex long bone non-unions after multiple surgical interventions.
METHODS & MATERIALS: Three patients with non-unions resulting from multiple surgical failures underwent bone stabilization along with the application of a novel bioregenerative scaffold. X-rays and subjective assessments were collected prior to surgery and at 6- and 12-months post-surgery.
RESULTS: All non-unions demonstrated healing with adequate callus formation, as confirmed by radiological assessments. By 12 months, all patients were able to resume full weight-bearing activities or regain full range of motion and physical strength without pain. Statistical analysis revealed improvements across all assessment scales compared to pre-surgical values.
CONCLUSION: This approach offers a viable option for treating complex long bone non-unions after multiple surgical interventions.