JAMA dermatology · 2024
Keratosis Pilaris-Like Reaction Associated With Chromatin Remodeling Complex Inhibition in Uveal Melanoma.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Seervai Riyad N H, Taylor Madison M, Rahbar Ziba, Patel Sapna P, Nelson Kelly C, Prieto Victor G, Curry Jonathan L
Аннотация
BACKGROUND: To evaluate the associations of the triglyceride-glucose (TyG) index and related obesity-combined indexes with the incidence of major vision-threatening ocular diseases.
METHODS: This prospective population-based cohort study included 400,237 participants from the UK Biobank. The TyG index and derived indexes (combined with waist circumference, waist-to-height ratio, and body mass index) were calculated using baseline laboratory and anthropometric data. The outcomes were incident cases of cataract, POAG, AMD, and diabetic retinopathy (DR), ascertained using self-reported data, hospital inpatient records, and primary care records. Cox proportional hazards models were used, with restricted cubic splines fitted to characterize dose-response relationships. Secondary analyses assessed the associations with retinal thicknesses and vascular features.
RESULTS: Over a median follow-up of 13.0 years, 46,151 cataract, 6317 POAG, 8276 AMD, and 5220 DR incident cases were identified. Distinct nonlinear associations were observed: the TyG index exhibited a reverse L-shaped relationship with cataract and DR, a J-shaped association with AMD, and a U-shaped relationship with POAG (all P total < 0.01, all P nonlinear < 0.05), suggesting an estimated optimal range from 8.6 to 9.1. Furthermore, elevated TyG-obesity indexes exhibited monotonic positive associations with the risk of cataract, AMD, and DR (all P total < 0.001), whereas moderate elevation was associated with a reduced risk of POAG (all P total < 0.01, all P nonlinear < 0.05). Elevated TyG-obesity indexes were also associated with retinal thinning and vascular abnormalities, providing supportive discrimination and risk-stratification information for incident DR.
CONCLUSIONS: The TyG index and related obesity-combined indexes show disease-specific associations with major sight-threatening conditions, accompanied by retinal structural alterations. Maintaining these parameters within optimal ranges could help mitigate the risk of vision impairment.
METHODS: This prospective population-based cohort study included 400,237 participants from the UK Biobank. The TyG index and derived indexes (combined with waist circumference, waist-to-height ratio, and body mass index) were calculated using baseline laboratory and anthropometric data. The outcomes were incident cases of cataract, POAG, AMD, and diabetic retinopathy (DR), ascertained using self-reported data, hospital inpatient records, and primary care records. Cox proportional hazards models were used, with restricted cubic splines fitted to characterize dose-response relationships. Secondary analyses assessed the associations with retinal thicknesses and vascular features.
RESULTS: Over a median follow-up of 13.0 years, 46,151 cataract, 6317 POAG, 8276 AMD, and 5220 DR incident cases were identified. Distinct nonlinear associations were observed: the TyG index exhibited a reverse L-shaped relationship with cataract and DR, a J-shaped association with AMD, and a U-shaped relationship with POAG (all P total < 0.01, all P nonlinear < 0.05), suggesting an estimated optimal range from 8.6 to 9.1. Furthermore, elevated TyG-obesity indexes exhibited monotonic positive associations with the risk of cataract, AMD, and DR (all P total < 0.001), whereas moderate elevation was associated with a reduced risk of POAG (all P total < 0.01, all P nonlinear < 0.05). Elevated TyG-obesity indexes were also associated with retinal thinning and vascular abnormalities, providing supportive discrimination and risk-stratification information for incident DR.
CONCLUSIONS: The TyG index and related obesity-combined indexes show disease-specific associations with major sight-threatening conditions, accompanied by retinal structural alterations. Maintaining these parameters within optimal ranges could help mitigate the risk of vision impairment.