Sexual medicine · 2025
The value of 5-HT, leptin, and NE in the classification of premature ejaculation.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chen Zhimin, Zhang Xiansheng
Аннотация
BACKGROUND: While premature ejaculation (PE) can be divided into lifelong PE (LPE), acquired PE, natural variable PE (NPE), and subjective PE (SPE), there is no objective method to classify PE.
AIM: To determine the value of serum serotonin (5-HT), leptin, and norepinephrine (NE) levels in the classification of PE.
METHODS: From July 2023 to July 2024, we recruited 150 participants and divided them into 4 groups: LPE (43 cases), NPE (32 cases), SPE (35 cases), and non-PE (40 cases) groups. All participants' baseline data, premature ejaculation diagnostic tool score, and intravaginal ejaculation latency time were investigated. In addition, all participants' serum 5-HT, leptin, and NE levels were measured.
OUTCOME: Serum 5-HT, NE, and leptin levels were compared among all groups.
RESULTS: Serum 5-HT levels were lower and NE and leptin levels were higher in the LPE group compared to the SPE, NPE, and non-PE groups (P < .05). However, serum 5-HT, leptin, and NE levels were not significantly different among the non-PE, NPE, and SPE groups (P < .05). In addition, serum 5-HT <95.0 ng/mL, NE >543.0 ng/L, and leptin >19.8 ng/mL may be predictive indicators of LPE.
CLINICAL SIGNIFICANCE: Based on serum 5-HT, NE, and leptin levels, LPE can be distinguished from SPE and NPE, which provides an objective basis for the treatment of PE.
STRENGTHS AND LIMITATIONS: There is no effective method to classify PE. The main limitation of this study is the limited sample size.
CONCLUSION: The serum 5-HT, leptin, and NE levels in PE patients may contribute to the classification of PE.
AIM: To determine the value of serum serotonin (5-HT), leptin, and norepinephrine (NE) levels in the classification of PE.
METHODS: From July 2023 to July 2024, we recruited 150 participants and divided them into 4 groups: LPE (43 cases), NPE (32 cases), SPE (35 cases), and non-PE (40 cases) groups. All participants' baseline data, premature ejaculation diagnostic tool score, and intravaginal ejaculation latency time were investigated. In addition, all participants' serum 5-HT, leptin, and NE levels were measured.
OUTCOME: Serum 5-HT, NE, and leptin levels were compared among all groups.
RESULTS: Serum 5-HT levels were lower and NE and leptin levels were higher in the LPE group compared to the SPE, NPE, and non-PE groups (P < .05). However, serum 5-HT, leptin, and NE levels were not significantly different among the non-PE, NPE, and SPE groups (P < .05). In addition, serum 5-HT <95.0 ng/mL, NE >543.0 ng/L, and leptin >19.8 ng/mL may be predictive indicators of LPE.
CLINICAL SIGNIFICANCE: Based on serum 5-HT, NE, and leptin levels, LPE can be distinguished from SPE and NPE, which provides an objective basis for the treatment of PE.
STRENGTHS AND LIMITATIONS: There is no effective method to classify PE. The main limitation of this study is the limited sample size.
CONCLUSION: The serum 5-HT, leptin, and NE levels in PE patients may contribute to the classification of PE.