Gut Microbiome profile on hirschsprung diseases with hirschsprung associated enterocolitis and non-hirschsprung associated enterocolitis: A systematic review.

INTRODUCTION: Hirschsprung's disease (HSCR), commonly known as aganglionic megacolon, is a rare congenital intestinal illness. Hirschsprung-associated enterocolitis (HAEC), an HSCR complication, is the major cause of morbidity and mortality in patients. Many research has highlighted specific microbiomes that promote HAEC, although there is still controversy on microbiome management. The aim of this study is to profile the gut microbiome of paediatric patients on HSCR with or without HAEC.

MATERIALS AND METHODS: We conducted an analytical descriptive systematic review of relevant case reports from inception research articles between January 2014 to October 2024 using 3 databases following PRISMA guidelines. We extracted data of gut microbiomes in humans with HSCR with or without HAEC. Data about microbiome's effects on gut physiology were also extracted.

RESULTS: This study identified 244 citations; 17 articles were included and analyzed. Proteobacteria were the most common bacteria in HSCR patients developing HAEC and Bacteroidetes were the most common bacteria found in HSCR patients without HAEC.

CONCLUSION: Proteobacteria were associated in HSCR patient developing HAEC. Therefore, gut microbiome dysbiosis may also be the key point to prevent HAEC.