Clinical neurophysiology practice · 2025
Asymptomatic tarsal tunnel syndrome in rheumatoid arthritis: An electrophysiological perspective with Insights into clinical and Laboratory correlates.
СтатьяНазвание и аннотация: Перевод в очереди
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Elshony Hosna, Aly Mohamed H, Mohammed Abdelgaffar, Hassan Abdulrahman M, Alshehri Abdulrahman A, Hedak Mohamed, Almuhanna Rakan, Al-Ghamdi Abdulaziz, Elsaadawy Rasha
Аннотация
OBJECTIVE: To evaluate the prevalence of asymptomatic tarsal tunnel syndrome (TTS) in rheumatoid arthritis (RA) patients and its association with disease activity, inflammation, and electrophysiological changes.
METHODS: Forty RA patients and 40 age- and sex-matched controls underwent nerve conduction studies assessing medial plantar, lateral plantar, and posterior tibial nerves. Disease activity (DAS28, RASS), inflammatory markers (ESR, CRP), and autoantibodies (RF, anti-CCP) were recorded. Comparisons used t-tests; correlations assessed associations.
RESULTS: RA patients showed significantly prolonged sensory latencies and reduced amplitudes and nerve conduction velocities, especially in medial and lateral plantar nerves. Sensory latencies had 100% sensitivity for subclinical TTS; motor parameters demonstrated high specificity. Higher DAS28, longer disease duration, elevated ESR/CRP, joint deformities, and seropositivity predicted TTS.
CONCLUSIONS: Subclinical TTS is highly prevalent in RA and linked to systemic inflammation, disease severity, and structural damage.
SIGNIFICANCE: Routine electrophysiological screening may enable early detection and intervention, preserving nerve function and improving long-term mobility and quality of life in RA patients.
TRIAL REGISTRATION: The study was approved by the SFHM Institutional Review Board and registered under HAP-02-K-052 in August 2024.
METHODS: Forty RA patients and 40 age- and sex-matched controls underwent nerve conduction studies assessing medial plantar, lateral plantar, and posterior tibial nerves. Disease activity (DAS28, RASS), inflammatory markers (ESR, CRP), and autoantibodies (RF, anti-CCP) were recorded. Comparisons used t-tests; correlations assessed associations.
RESULTS: RA patients showed significantly prolonged sensory latencies and reduced amplitudes and nerve conduction velocities, especially in medial and lateral plantar nerves. Sensory latencies had 100% sensitivity for subclinical TTS; motor parameters demonstrated high specificity. Higher DAS28, longer disease duration, elevated ESR/CRP, joint deformities, and seropositivity predicted TTS.
CONCLUSIONS: Subclinical TTS is highly prevalent in RA and linked to systemic inflammation, disease severity, and structural damage.
SIGNIFICANCE: Routine electrophysiological screening may enable early detection and intervention, preserving nerve function and improving long-term mobility and quality of life in RA patients.
TRIAL REGISTRATION: The study was approved by the SFHM Institutional Review Board and registered under HAP-02-K-052 in August 2024.