Journal of cosmetic dermatology · 2026
The ARTIST Post-Market Study: Evaluating a High G' Hyaluronic Acid (HA) Injectable for Chin Combined With Midface HA Filler Treatments.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Nikolis Andreas, Rivers Jason K, Rosen Nathan, Weinberg Felipe, Prygova Inna, Bromée Torun
Аннотация
BACKGROUND: A novel hyaluronic acid (HA) injectable (Restylane Shaype, HASHA) with high strength/firmness and enhanced HA concentration, optimized for lower face shaping has been developed.
AIMS: This prospective, 8-week, multicenter, post-market study evaluated three treatment algorithms, i.e., the Shayping Technique, for subjects with multiple aesthetic needs, including HASHA for chin augmentation alone/in combination with treatments for the lower face and midface with HADEF (Restylane Defyne) and HALYF (Restylane Lyft Lidocaine).
PATIENTS/METHODS: Subjects ≥ 18 years were assigned to one of the following treatments: Group 1: HASHA (chin); Group 2: HASHA (chin) and HADEF (marionette line areas laterally to the chin); Group 3: HASHA (chin), HADEF (marionette line areas laterally to the chin), and HALYF (midface and/or nasolabial fold [NLF, piriform fossa] and/or jawline). Assessments included Global Aesthetic Improvement Scale (GAIS), subject and investigator satisfaction, and collection of adverse events (AEs).
RESULTS: The GAIS responder rate ("improved," "much improved," or "very much improved") was 100% in all groups at Week 8 (primary endpoint) and Week 4 as assessed by the investigator and by subject self-assessment at Weeks 4 and 8. Overall subject and investigator satisfaction with treatment was high, and the safety profile for all product combinations was favorable, with no unexpected AEs.
CONCLUSIONS: Treatment with HASHA for chin augmentation alone/in combination with HADEF and HALYF for comprehensive lower face and midface lift was safe and effective, with 100% aesthetic improvement at 8 weeks post-injection. The Shayping Technique provides standardized guidance for practitioners to perform safe injections and achieve optimal aesthetic outcomes.
AIMS: This prospective, 8-week, multicenter, post-market study evaluated three treatment algorithms, i.e., the Shayping Technique, for subjects with multiple aesthetic needs, including HASHA for chin augmentation alone/in combination with treatments for the lower face and midface with HADEF (Restylane Defyne) and HALYF (Restylane Lyft Lidocaine).
PATIENTS/METHODS: Subjects ≥ 18 years were assigned to one of the following treatments: Group 1: HASHA (chin); Group 2: HASHA (chin) and HADEF (marionette line areas laterally to the chin); Group 3: HASHA (chin), HADEF (marionette line areas laterally to the chin), and HALYF (midface and/or nasolabial fold [NLF, piriform fossa] and/or jawline). Assessments included Global Aesthetic Improvement Scale (GAIS), subject and investigator satisfaction, and collection of adverse events (AEs).
RESULTS: The GAIS responder rate ("improved," "much improved," or "very much improved") was 100% in all groups at Week 8 (primary endpoint) and Week 4 as assessed by the investigator and by subject self-assessment at Weeks 4 and 8. Overall subject and investigator satisfaction with treatment was high, and the safety profile for all product combinations was favorable, with no unexpected AEs.
CONCLUSIONS: Treatment with HASHA for chin augmentation alone/in combination with HADEF and HALYF for comprehensive lower face and midface lift was safe and effective, with 100% aesthetic improvement at 8 weeks post-injection. The Shayping Technique provides standardized guidance for practitioners to perform safe injections and achieve optimal aesthetic outcomes.