Head & neck · 2026
Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications.
СтатьяНазвание и аннотация: Перевод в очереди
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Allen David Z, Hosseini S Mohsen, Zafereo Mark, Lango Miriam, Grubbs Elizabeth Gardner, Iyer Priyanka, Patel Shreyaskumar R, Ravi Vinod, Busaidy Naifa Lamki, Wang Rui Jennifer, Williams Michelle D, Cabanillas Maria E, Maniakas Anastasios
Аннотация
BACKGROUND: Beyond follicular-derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers.
METHODS: Retrospective case series.
RESULTS: Eight patients with aggressive thyroid tumors presented with clinical and radiographic features concerning for anaplastic thyroid cancer (ATC). Three patients presumed to be diagnosed with Adamantinoma-like Ewing sarcoma (ALES), each harboring an EWSR1-FLI1 rearrangement. One patient with an enlarging neck mass was found to have osteoid-producing osteosarcoma. Another patient with a bulky neck mass and metastases demonstrated neolumen and ERG/CD31 positivity, confirming thyroid angiosarcoma. A separate patient was diagnosed with a high-grade sarcoma harboring a PRMT8-NTRK fusion, representing the first reported case. Two patients had mucoepidermoid carcinoma (MEC) variants-one classic MEC and one sclerosing MEC with eosinophilia (SMECE).
CONCLUSIONS: Multiple rare thyroid malignancies may present indistinguishably from ATC, emphasizing the need for meticulous histopathologic and molecular evaluation.
METHODS: Retrospective case series.
RESULTS: Eight patients with aggressive thyroid tumors presented with clinical and radiographic features concerning for anaplastic thyroid cancer (ATC). Three patients presumed to be diagnosed with Adamantinoma-like Ewing sarcoma (ALES), each harboring an EWSR1-FLI1 rearrangement. One patient with an enlarging neck mass was found to have osteoid-producing osteosarcoma. Another patient with a bulky neck mass and metastases demonstrated neolumen and ERG/CD31 positivity, confirming thyroid angiosarcoma. A separate patient was diagnosed with a high-grade sarcoma harboring a PRMT8-NTRK fusion, representing the first reported case. Two patients had mucoepidermoid carcinoma (MEC) variants-one classic MEC and one sclerosing MEC with eosinophilia (SMECE).
CONCLUSIONS: Multiple rare thyroid malignancies may present indistinguishably from ATC, emphasizing the need for meticulous histopathologic and molecular evaluation.