Frontiers in molecular biosciences · 2026
Diagnostic and short-term prognosis value of serum ox-LDL/LOX-1 and GDF-15 in elderly patients with acute coronary syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Jinlin, Guo Tong, Liu Fengzhen, Pei Xueliang, Guo Fengxia, Li Hanxiao, Cui Facai
Аннотация
BACKGROUND: In the diagnosis and short-term prognosis of elderly patients with acute coronary syndrome (ACS), there has been a persistent lack of effective biomarkers. This study aimed to investigate the expression characteristics of serum oxidized-low-density lipoprotein (ox-LDL), lectin-like-oxidized low-density-lipoprotein receptor-1 (LOX-1), and growth-differentiation-factor 15 (GDF-15) in elderly ACS patients and assess their short-term prognostic value.
METHODS: 161 elderly patients with ACS and 66 elderly patients with non-ACS were enrolled. Subgroup classification included the ST-elevation myocardial infarction (STEMI), unstable-angina-pectoris (UAP) and NSTEMI. Serum ox-LDL, LOX-1 and GDF-15 were evaluated via ELISA assay. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value. The prognosis of ACS patients was determined by Major-Adverse-Cardiovascular-Events (MACE) as the outcome. The short-term prognosis value of 3 serum biomarkers was evaluated using multivariate logistic analysis.
RESULTS: Ox-LDL, LOX-1, and GDF-15 levels in serum were significantly higher in elderly patients with ACS (all P < 0.001). The ROC analysis results showed that GDF-15 (AUC = 0.884) had high accuracy in diagnosing elderly patients with ACS. In subgroup analysis, serum levels of ox-LDL (P < 0.001) and LOX-1 (P < 0.05) were significantly lower in the UAP group than in the STEMI and NSTEMI groups. The APACHE II score (P = 0.005) and GDF-15 level (P < 0.001) were significantly higher in the MACE group. Multivariate logistic analyses further demonstrated that GDF-15 was an independent predictor of MACE in elderly ACS patients (P = 0.011).
CONCLUSION: High serum GDF-15 levels are significantly associated with the presence of ACS and, in ACS patients, are significantly higher in those who do develop MACE. Serum GDF-15 can serve as an independent predictor of short-term MACE risk in elderly patients with ACS.
METHODS: 161 elderly patients with ACS and 66 elderly patients with non-ACS were enrolled. Subgroup classification included the ST-elevation myocardial infarction (STEMI), unstable-angina-pectoris (UAP) and NSTEMI. Serum ox-LDL, LOX-1 and GDF-15 were evaluated via ELISA assay. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value. The prognosis of ACS patients was determined by Major-Adverse-Cardiovascular-Events (MACE) as the outcome. The short-term prognosis value of 3 serum biomarkers was evaluated using multivariate logistic analysis.
RESULTS: Ox-LDL, LOX-1, and GDF-15 levels in serum were significantly higher in elderly patients with ACS (all P < 0.001). The ROC analysis results showed that GDF-15 (AUC = 0.884) had high accuracy in diagnosing elderly patients with ACS. In subgroup analysis, serum levels of ox-LDL (P < 0.001) and LOX-1 (P < 0.05) were significantly lower in the UAP group than in the STEMI and NSTEMI groups. The APACHE II score (P = 0.005) and GDF-15 level (P < 0.001) were significantly higher in the MACE group. Multivariate logistic analyses further demonstrated that GDF-15 was an independent predictor of MACE in elderly ACS patients (P = 0.011).
CONCLUSION: High serum GDF-15 levels are significantly associated with the presence of ACS and, in ACS patients, are significantly higher in those who do develop MACE. Serum GDF-15 can serve as an independent predictor of short-term MACE risk in elderly patients with ACS.