The Polymorphic Analysis of the Human Potassium Channel KCNE Gene Family in Meniere's Disease-A Preliminary Study.

OBJECTIVES

To investigate the correlation between KCNE gene family and Meniere's disease (MD) in the Chinese population.

MATERIALS AND

METHODS

This study analyzed the single-nucleotide polymorphism (SNP) of KCNE1 and KCNE3 genes between the MD group and the control group and between the familial Meniere's disease (FMD) group and the sporadic Meniere's disease (SMD) group.

RESULTS

A total of 653 C/T SNPs of KCNE1 had a statistical difference between the FMD and SMD groups (p=0.0082<0.05); 492 A/C SNPs of KCNE3 were statistically different between the FMD group and the control group (genotype p=0.037<0.05 and allele p=0.006<0.05).

CONCLUSION

SNPs of KCNE1 and KCNE3 gene mutations were, respectively, different between the SMD and FMD groups. KCNE3 gene polymorphism was key to FMD disease, whereas KCNE1 was more important to the onset of SMD.