Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2016
Portal vein thrombosis associated with protein C deficiency and elevated Factor VIII in hepatosplenic schistosomiasis.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Leite Luiz Arthur Calheiros, Ferreira Rita de Cássia dos Santos, Hatzlhofer Betânia Lucena Domingues, Correia Maria Conceição Barros, Bandeira Ângela Pontes, Owen James Stuart, Lima Vera Lúcia de Menezes, Domingues Ana Lúcia Coutinho, Lopes Edmundo Pessoa
Аннотация
Portal vein thrombosis is considered a vaso-occlusive process that can appear during the course of hepatosplenic Schistosoma mansoni, but may result from impaired portal blood flow or be associated with acquired or inherited thrombophilic factors. Here, we report the case of a 67-year-old woman who developed thrombocytopenia as a result of hypersplenism. Following the diagnosis of hepatosplenic schistosomiasis, portal vein thrombosis was detected by ultrasound examination, while haematological tests revealed low levels of protein C (43.3%) and high levels of factor VIII (183.1%). The pathogenesis of portal vein thrombosis remains unclear in some patients with S. mansoni. We recommend, therefore, that early clinical and haemostatic investigations are done to evaluate risk of portal vein thrombosis and hence avoid further complications.